SPRR2D and PKN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SPRR2D	PKN1
Description		small proline rich protein 2D	protein kinase N1
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex
	Molecular Function		Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity
	Biological Process	Epidermis Development Keratinization	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility
Pathways		Formation of the cornified envelope	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		2 interacting genes: MAPK6 PKN1	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		6703	5585
HPRD ID			03019
Ensembl ID		ENSG00000163216	ENSG00000123143
Uniprot IDs		P22532	Q16512
PDB IDs			1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?		Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation Histone H3T11 Kinase Activity Protein Serine/threonine Kinase Activity Septin Cytoskeleton Regulation Of Germinal Center Formation Protein Kinase Activity Kinase Activity B Cell Apoptotic Process Negative Regulation Of B Cell Proliferation Protein-containing Complex Diacylglycerol-dependent Serine/threonine Kinase Activity MAP Kinase Activity Nuclear Androgen Receptor Binding Hyperosmotic Response B Cell Homeostasis Epithelial Cell Migration Negative Regulation Of B Cell Activation Regulation Of Androgen Receptor Signaling Pathway Lymphocyte Apoptotic Process Positive Regulation Of Dendritic Spine Development Spleen Development Phosphate-containing Compound Metabolic Process Leukocyte Apoptotic Process Protein Kinase C Binding Cleavage Furrow Regulation Of Dendritic Spine Development ATP Binding Lymphocyte Homeostasis Regulation Of B Cell Proliferation Protein Modification Process Nucleotide Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Lymphocyte Proliferation Response To Osmotic Stress Negative Regulation Of Mononuclear Cell Proliferation Transferase Activity Intracellular Signal Transduction Regulation Of Immunoglobulin Production Leukocyte Homeostasis Hematopoietic Or Lymphoid Organ Development Negative Regulation Of Leukocyte Proliferation Renal System Process Regulation Of B Cell Activation Histone Deacetylase Binding Ameboidal-type Cell Migration	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion
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