SOD1 and UBE3A

Number of citations of the paper that reports this interaction (PMID 23040663)
5

Data Source:
BioGRID (pull down)

		SOD1	UBE3A
Gene Name		superoxide dismutase 1, soluble	ubiquitin protein ligase E3A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Peroxisome Cytosol Plasma Membrane Extracellular Matrix Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Protein Complex Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Protein Phosphatase 2B Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding Chaperone Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	Activation Of MAPK Activity Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Platelet Degranulation Glutathione Metabolic Process Superoxide Metabolic Process Cellular Iron Ion Homeostasis Spermatogenesis Embryo Implantation Cell Aging Blood Coagulation Sensory Perception Of Sound Locomotory Behavior Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Regulation Of Blood Pressure Response To Heat Response To Organic Substance Transmission Of Nerve Impulse Removal Of Superoxide Radicals Platelet Activation Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Regulation Of Rac GTPase Activity Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Drug Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Protein Kinase Activity Regulation Of Organ Growth Response To Antibiotic Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Regulation Of Mitochondrial Membrane Potential Oxidation-reduction Process Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Response to elevated platelet cytosolic Ca2+ Detoxification of Reactive Oxygen Species Platelet degranulation Platelet activation, signaling and aggregation	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 20801718)	Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: AMFR BCL2 CCS CRYAB DNAJB1 HOXB2 HSPA4 KARS MARCH5 PARK7 PPP3CA RNF19A SMAD2 UBE3A	80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID		6647	7337
HPRD ID		00937	03375
Ensembl ID		ENSG00000142168	ENSG00000114062
Uniprot IDs		P00441	Q05086 Q9BUI6 Q9H2G0
PDB IDs		1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4SOD	1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Protein Polyubiquitination Response To Reactive Oxygen Species Response To Inorganic Substance Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Organ Growth Response To Organic Substance Reactive Oxygen Species Metabolic Process Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Regulation Of Protein Homodimerization Activity Response To Unfolded Protein Negative Regulation Of Transport Response To Oxidative Stress Regulation Of Intracellular Transport Cellular Response To Stress Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Mitochondrial Membrane Potential Cellular Response To Oxidative Stress Positive Regulation Of Oxidoreductase Activity Response To Stress Protein Autoubiquitination Regulation Of Binding Response To Gamma Radiation Regulation Of Cellular Component Organization Neural Nucleus Development Regulation Of Membrane Potential Developmental Growth Positive Regulation Of Mitochondrion Organization Mitochondrial Membrane Organization Lysyl-tRNA Aminoacylation Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Sperm Entry Negative Regulation Of Cellular PH Reduction Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Transition Between Fast And Slow Fiber CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity	Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Difference) ?		alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Intersection) ?