SOD1 and KARS1

Number of citations of the paper that reports this interaction (PubMedID 18715867)
42

Data Source:
HPRD (in vivo)

		SOD1	KARS1
Description		superoxide dismutase 1	lysyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Peroxisome Cytosol Plasma Membrane Secretory Granule Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Protein-containing Complex Neuronal Cell Body Extracellular Exosome Axon Cytoplasm	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Antioxidant Activity Oxidoreductase Activity Enzyme Binding Protein Phosphatase 2B Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding	TRNA Binding Nucleotide Binding Nucleic Acid Binding ATP:ADP Adenylyltransferase Activity Aminoacyl-tRNA Ligase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Transferase Activity Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Glutathione Metabolic Process Superoxide Metabolic Process Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Spermatogenesis Embryo Implantation Sensory Perception Of Sound Locomotory Behavior Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Blood Pressure Determination Of Adult Lifespan Response To Heat Response To Xenobiotic Stimulus Gene Expression Transmission Of Nerve Impulse Neuronal Action Potential Removal Of Superoxide Radicals Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Oxidative Stress Ectopic Germ Cell Programmed Cell Death Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Regulation Of Organ Growth Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Negative Regulation Of Developmental Process Regulation Of Mitochondrial Membrane Potential Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Associated Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Action Potential Initiation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reproductive Process	Basophil Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Antigenic Stimulus Translation TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Response To X-ray Diadenosine Tetraphosphate Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of DNA-templated Transcription ERK1 And ERK2 Cascade
Pathways		Platelet degranulation Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Dopamine Isoprenaline Zinc 5-fluorouridine S-oxy-L-cysteine Arimoclomol Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Lysine
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Amyotrophic lateral sclerosis ( 20801718)
Interacting Genes		18 interacting genes: AMFR BCL2 CCS COMMD1 CRYAB DNAJB1 FNDC3B HOXB2 KARS1 MARCHF5 MYCBP2 PARK7 PAX6 PPP3CA RANBP9 RNF19A SMAD2 UBE3A	87 interacting genes: AIMP2 CDC42 CEBPA DARS2 DYSF EEF1D EEF1G ESR1 FNDC3B FRS3 GAPDH GEMIN4 LINC01554 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-2 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 SUMO2 VIM
Entrez ID		6647	3735
HPRD ID		00937	03249
Ensembl ID		ENSG00000142168	ENSG00000065427
Uniprot IDs		P00441 V9HWC9	Q15046
PDB IDs		1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4MCM 4MCN 4NIN 4NIO 4NIP 4OH2 4XCR 5DLI 5IIW 5J07 5J0C 5J0F 5J0G 5K02 5O3Y 5O40 5U9M 5WMJ 5WOR 5YTO 5YTU 5YUL 6A9O 6B79 6DTK 6FFK 6FLH 6FOI 6FOL 6FON 6FP6 6SPA 6SPH 6SPI 6SPJ 6SPK 6Z3V 6Z4G 6Z4H 6Z4I 6Z4J 6Z4K 6Z4L 6Z4M 6Z4O 7CJV 7CJW 7FB6 7FB9 7NXX 7T8E 7T8F 7T8G 7T8H 7VZF 7XX3 8CCX 8GSQ 8IHU 8IHV 8K33 8K3A 8K3L 8Q6M 8YAT 8YD3 9IYK 9JBO 9JBP	3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH 7EA9 8HYR 8XP4 9DOW 9DPA 9DPB 9DPL
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Superoxide Dismutase Copper Chaperone Activity Cytosol Protein Polyubiquitination Post-translational Protein Modification Organ Growth Copper Ion Binding Ubiquitin Protein Ligase Activity Intracellular Signal Transduction Protein Autoubiquitination Identical Protein Binding Protein Ubiquitination Cytoplasm Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Co-SMAD Binding Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process Negative Regulation Of Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Dorsal/ventral Axis Specification Removal Of Superoxide Radicals Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Reactive Oxygen Species Metabolic Process Ubiquitin-specific Protease Binding Response To Hydrogen Peroxide Negative Regulation Of Monoatomic Ion Transport Neuron Projection Morphogenesis Ubiquitin Ligase Complex Cell Projection Morphogenesis Mitochondrion Positive Regulation Of Protein Ubiquitination Protein Modification Process Androgen Receptor Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Transmembrane Transport Intracellular Signaling Cassette Embryonic Organ Morphogenesis R-SMAD Binding Positive Regulation Of Post-translational Protein Modification Skeletal Muscle Fiber Development Gland Morphogenesis Response To Ionizing Radiation	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation Negative Regulation Of Cell Migration MRNA Destabilization Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Translation Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Regulation Of Cell Migration Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vasculature Development Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Locomotion Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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