SOD1 and PPP3CA

Number of citations of the paper that reports this interaction (PMID 11513882)
1

Data Source:
HPRD (in vitro)

		SOD1	PPP3CA
Gene Name		superoxide dismutase 1, soluble	protein phosphatase 3, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Peroxisome Cytosol Plasma Membrane Extracellular Matrix Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Protein Complex Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Protein Phosphatase 2B Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding Chaperone Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Activation Of MAPK Activity Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Platelet Degranulation Glutathione Metabolic Process Superoxide Metabolic Process Cellular Iron Ion Homeostasis Spermatogenesis Embryo Implantation Cell Aging Blood Coagulation Sensory Perception Of Sound Locomotory Behavior Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Regulation Of Blood Pressure Response To Heat Response To Organic Substance Transmission Of Nerve Impulse Removal Of Superoxide Radicals Platelet Activation Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Regulation Of Rac GTPase Activity Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Drug Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Protein Kinase Activity Regulation Of Organ Growth Response To Antibiotic Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Regulation Of Mitochondrial Membrane Potential Oxidation-reduction Process Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Response to elevated platelet cytosolic Ca2+ Detoxification of Reactive Oxygen Species Platelet degranulation Platelet activation, signaling and aggregation	Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 20801718)	Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		14 interactors: AMFR BCL2 CCS CRYAB DNAJB1 HOXB2 HSPA4 KARS MARCH5 PARK7 PPP3CA RNF19A SMAD2 UBE3A	24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1
Entrez ID		6647	5530
HPRD ID		00937	00234
Ensembl ID		ENSG00000142168	ENSG00000138814
Uniprot IDs		P00441	Q08209
PDB IDs		1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4SOD	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Protein Polyubiquitination Response To Reactive Oxygen Species Response To Inorganic Substance Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Organ Growth Response To Organic Substance Reactive Oxygen Species Metabolic Process Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Regulation Of Protein Homodimerization Activity Response To Unfolded Protein Negative Regulation Of Transport Response To Oxidative Stress Regulation Of Intracellular Transport Cellular Response To Stress Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Mitochondrial Membrane Potential Cellular Response To Oxidative Stress Positive Regulation Of Oxidoreductase Activity Response To Stress Protein Autoubiquitination Regulation Of Binding Response To Gamma Radiation Regulation Of Cellular Component Organization Neural Nucleus Development Regulation Of Membrane Potential Developmental Growth Positive Regulation Of Mitochondrion Organization Mitochondrial Membrane Organization Lysyl-tRNA Aminoacylation Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Sperm Entry Negative Regulation Of Cellular PH Reduction Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Transition Between Fast And Slow Fiber CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity	Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death
Tagcloud ?		alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Difference) ?		alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Intersection) ?