SOD1 and DNAJB1

Number of citations of the paper that reports this interaction (PMID 11457725)
17

Data Source:
HPRD (in vivo)

		SOD1	DNAJB1
Gene Name		superoxide dismutase 1, soluble	DnaJ (Hsp40) homolog, subfamily B, member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Peroxisome Cytosol Plasma Membrane Extracellular Matrix Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Protein Phosphatase 2B Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding Chaperone Binding	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Unfolded Protein Binding Chaperone Binding ATPase Binding
	Biological Process	Activation Of MAPK Activity Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Platelet Degranulation Glutathione Metabolic Process Superoxide Metabolic Process Cellular Iron Ion Homeostasis Spermatogenesis Embryo Implantation Cell Aging Blood Coagulation Sensory Perception Of Sound Locomotory Behavior Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Regulation Of Blood Pressure Response To Heat Response To Organic Substance Transmission Of Nerve Impulse Removal Of Superoxide Radicals Platelet Activation Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Regulation Of Rac GTPase Activity Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Drug Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Protein Kinase Activity Regulation Of Organ Growth Response To Antibiotic Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Regulation Of Mitochondrial Membrane Potential Oxidation-reduction Process Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Response To Unfolded Protein Positive Regulation Of ATPase Activity Cellular Response To Heat Chaperone Mediated Protein Folding Requiring Cofactor Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat
Pathways		Response to elevated platelet cytosolic Ca2+ Detoxification of Reactive Oxygen Species Platelet degranulation Platelet activation, signaling and aggregation	HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 20801718)
Protein-Protein Interactions		14 interactors: AMFR BCL2 CCS CRYAB DNAJB1 HOXB2 HSPA4 KARS MARCH5 PARK7 PPP3CA RNF19A SMAD2 UBE3A	28 interactors: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 ZFP36
Entrez ID		6647	3337
HPRD ID		00937	05198
Ensembl ID		ENSG00000142168	ENSG00000132002
Uniprot IDs		P00441	B4DX52 P25685 Q6FHS4
PDB IDs		1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4SOD	1HDJ 2QLD 3AGX 3AGY 3AGZ
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Protein Polyubiquitination Response To Reactive Oxygen Species Response To Inorganic Substance Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Organ Growth Response To Organic Substance Reactive Oxygen Species Metabolic Process Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Regulation Of Protein Homodimerization Activity Response To Unfolded Protein Negative Regulation Of Transport Response To Oxidative Stress Regulation Of Intracellular Transport Cellular Response To Stress Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Mitochondrial Membrane Potential Cellular Response To Oxidative Stress Positive Regulation Of Oxidoreductase Activity Response To Stress Protein Autoubiquitination Regulation Of Binding Response To Gamma Radiation Regulation Of Cellular Component Organization Neural Nucleus Development Regulation Of Membrane Potential Developmental Growth Positive Regulation Of Mitochondrion Organization Mitochondrial Membrane Organization Lysyl-tRNA Aminoacylation Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Sperm Entry Negative Regulation Of Cellular PH Reduction Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Transition Between Fast And Slow Fiber CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity	Response To Stress Response To Stimulus Response To External Stimulus Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Temperature Stimulus Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Protein Metabolic Process Response To Unfolded Protein Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Protein Refolding Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Response To Superoxide Response To Oxygen Radical Chemotaxis Regulation Of Cell Death Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Oxidative Stress Blood Coagulation Hemostasis Reactive Oxygen Species Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Differentiation Superoxide Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Cellular Component Organization
Tagcloud ?		alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?