SOD1 and RANBP9

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SOD1	RANBP9
Description		superoxide dismutase 1	RAN binding protein 9
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Peroxisome Cytosol Plasma Membrane Secretory Granule Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Protein-containing Complex Neuronal Cell Body Extracellular Exosome Axon Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Antioxidant Activity Oxidoreductase Activity Enzyme Binding Protein Phosphatase 2B Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding	Protein Binding Enzyme Binding Small GTPase Binding
	Biological Process	Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Glutathione Metabolic Process Superoxide Metabolic Process Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Spermatogenesis Embryo Implantation Sensory Perception Of Sound Locomotory Behavior Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Blood Pressure Determination Of Adult Lifespan Response To Heat Response To Xenobiotic Stimulus Gene Expression Transmission Of Nerve Impulse Neuronal Action Potential Removal Of Superoxide Radicals Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Oxidative Stress Ectopic Germ Cell Programmed Cell Death Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Regulation Of Organ Growth Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Negative Regulation Of Developmental Process Regulation Of Mitochondrial Membrane Potential Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Associated Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Action Potential Initiation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reproductive Process	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Platelet degranulation Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism
Drugs		Dopamine Isoprenaline Zinc 5-fluorouridine S-oxy-L-cysteine Arimoclomol Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Amyotrophic lateral sclerosis ( 20801718)	Breast cancer ( 23535729 29059683)
Interacting Genes		18 interacting genes: AMFR BCL2 CCS COMMD1 CRYAB DNAJB1 FNDC3B HOXB2 KARS1 MARCHF5 MYCBP2 PARK7 PAX6 PPP3CA RANBP9 RNF19A SMAD2 UBE3A	67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1
Entrez ID		6647	10048
HPRD ID		00937	04835
Ensembl ID		ENSG00000142168	ENSG00000010017
Uniprot IDs		P00441 V9HWC9	Q96S59
PDB IDs		1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4MCM 4MCN 4NIN 4NIO 4NIP 4OH2 4XCR 5DLI 5IIW 5J07 5J0C 5J0F 5J0G 5K02 5O3Y 5O40 5U9M 5WMJ 5WOR 5YTO 5YTU 5YUL 6A9O 6B79 6DTK 6FFK 6FLH 6FOI 6FOL 6FON 6FP6 6SPA 6SPH 6SPI 6SPJ 6SPK 6Z3V 6Z4G 6Z4H 6Z4I 6Z4J 6Z4K 6Z4L 6Z4M 6Z4O 7CJV 7CJW 7FB6 7FB9 7NXX 7T8E 7T8F 7T8G 7T8H 7VZF 7XX3 8CCX 8GSQ 8IHU 8IHV 8K33 8K3A 8K3L 8Q6M 8YAT 8YD3 9IYK 9JBO 9JBP	5JI7 5JI9 5JIU 7NSC
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Superoxide Dismutase Copper Chaperone Activity Cytosol Protein Polyubiquitination Post-translational Protein Modification Organ Growth Copper Ion Binding Ubiquitin Protein Ligase Activity Intracellular Signal Transduction Protein Autoubiquitination Identical Protein Binding Protein Ubiquitination Cytoplasm Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Co-SMAD Binding Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process Negative Regulation Of Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Dorsal/ventral Axis Specification Removal Of Superoxide Radicals Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Reactive Oxygen Species Metabolic Process Ubiquitin-specific Protease Binding Response To Hydrogen Peroxide Negative Regulation Of Monoatomic Ion Transport Neuron Projection Morphogenesis Ubiquitin Ligase Complex Cell Projection Morphogenesis Mitochondrion Positive Regulation Of Protein Ubiquitination Protein Modification Process Androgen Receptor Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Transmembrane Transport Intracellular Signaling Cassette Embryonic Organ Morphogenesis R-SMAD Binding Positive Regulation Of Post-translational Protein Modification Skeletal Muscle Fiber Development Gland Morphogenesis Response To Ionizing Radiation	Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway
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