SNTB2 and KCNJ12

Number of citations of the paper that reports this interaction (PMID 15024025)
29

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SNTB2	KCNJ12
Gene Name		syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	potassium channel, inwardly rectifying subfamily J, member 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Transport Vesicle Membrane Protein Complex Synapse Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Membrane
	Molecular Function	Actin Binding Protein Binding Calmodulin Binding Poly(A) RNA Binding	Inward Rectifier Potassium Channel Activity
	Biological Process		Potassium Ion Transport Muscle Contraction Synaptic Transmission Regulation Of Heart Contraction Potassium Ion Import Regulation Of Ion Transmembrane Transport Protein Homotetramerization
Pathways			GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs			Dofetilide
Diseases
GWAS			Height ( 20881960)
Protein-Protein Interactions		15 interactors: ABCA1 ADRA1D BAI1 DGKZ DMD DTNA ERBB4 KCNJ12 MAST1 MAST2 PTPRN SCN4A SCN5A UBC UTRN	16 interactors: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		6645	3768
HPRD ID		02491	09083
Ensembl ID		ENSG00000168807	ENSG00000184185
Uniprot IDs		Q13425	Q14500
PDB IDs		2VRF
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Signaling Cell Communication Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Cell-cell Signaling Action Potential Striated Muscle Contraction Regulation Of Ion Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transmembrane Transporter Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Positive Regulation Of Sodium Ion Transport Signal Transduction Cellular Response To Stimulus Cardiac Muscle Contraction Positive Regulation Of Cell-matrix Adhesion Regulation Of Membrane Potential Transmission Of Nerve Impulse Cardiac Muscle Tissue Regeneration Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Heart Contraction Peptide Secretion Blood Circulation Positive Regulation Of Transport Ion Transmembrane Transport Mitotic G1 DNA Damage Checkpoint Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Striated Muscle Contraction Central Nervous System Morphogenesis Establishment Of Glial Blood-brain Barrier Dense Core Granule Maturation Cell Projection Morphogenesis Cell Surface Receptor Signaling Pathway Peptide Transport Movement Of Cell Or Subcellular Component Mitotic DNA Damage Checkpoint Cell Part Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Peptidyl-cysteine S-nitrosylation	Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Maintenance Of Cell Polarity Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Protein Localization To Membrane Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Membrane Organization Cellular Protein Localization Receptor Clustering Regulation Of Ion Transmembrane Transport Muscle Contraction Muscle System Process Protein Localization Asymmetric Protein Localization Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Ion Transport Regulation Of Sodium Ion Transmembrane Transport Secretion Protein Localization To Plasma Membrane Cellular Localization Endomembrane System Organization Regulation Of Sodium Ion Transport Plasma Membrane Organization Secretion By Cell Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Movement Of Cell Or Subcellular Component Anatomical Structure Development Nucleotide Metabolic Process Regulation Of Membrane Potential Regulation Of Striated Muscle Contraction Chemotaxis Nervous System Development System Development Nucleobase-containing Small Molecule Metabolic Process Neurotransmitter Secretion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Exocytosis Developmental Process Signaling Cellular Component Assembly Cell Communication Axon Guidance
Tagcloud ?		adp cleaved clonogenic concomitantly degs discovering ebp elucidating exhibiting fractionated grp78 h1299 h2ax h460 h460r helpful ionizing ir metalloproteinase organelles overcome parental radioresistance radioresistant ribose scattering syntrophin vesicular zymography
Tagcloud (Difference) ?		adp cleaved clonogenic concomitantly degs discovering ebp elucidating exhibiting fractionated grp78 h1299 h2ax h460 h460r helpful ionizing ir metalloproteinase organelles overcome parental radioresistance radioresistant ribose scattering syntrophin vesicular zymography
Tagcloud (Intersection) ?