SNTB2 and SCN4A

Number of citations of the paper that reports this interaction (PubMedID 9412493)
64

Data Source:
HPRD (in vivo)

		SNTB2	SCN4A
Description		syntrophin beta 2	sodium voltage-gated channel alpha subunit 4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Centriolar Satellite Ciliary Basal Body Synapse Anchoring Junction	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding
	Biological Process		Action Potential Monoatomic Ion Transport Sodium Ion Transport Muscle Contraction Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Skeletal Muscle Contraction By Action Potential
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Topiramate Lidocaine Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Flecainide Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Parachlorophenol Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases			Congenital myasthenic syndrome Hyperkalemic periodic paralysis (HyperPP) Hypokalemic periodic paralysis (HypoPP) Paramyotonia congenita (PMC) Potassium-aggravated myotonias (PAMs), including: Myotonia fluctuans; Myotonia permanens; Acetazolamide responsive myotonia
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287) Logical memory (delayed recall) in normal cognition ( 29274321)	Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: ABCA1 ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAST1 MAST2 PTEN PTPRN SCN4A SCN5A UBC UTRN	10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN NHERF1 PATJ SNTA1 SNTB1 SNTB2
Entrez ID		6645	6329
HPRD ID		02491	04912
Ensembl ID		ENSG00000168807	ENSG00000007314
Uniprot IDs		Q13425	P35499
PDB IDs		2VRF	6AGF 6MBA 6MC9
Enriched GO Terms of Interacting Partners?		Plasma Membrane Muscle Contraction Muscle System Process Sarcolemma Regulation Of System Process Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Membrane Cell Communication System Process Regulation Of Sodium Ion Transport PDZ Domain Binding Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Blood Circulation Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Voltage-gated Sodium Channel Activity Synapse Regulation Of Monoatomic Ion Transmembrane Transport Filopodium Membrane Action Potential Regulation Of Skeletal Muscle Contraction Regulation Of Biological Quality Cell-cell Signaling Muscle Organ Development Monoatomic Ion Channel Complex Signaling Synaptic Signaling Muscle Structure Development Regulation Of Transport Phagocytosis, Engulfment Phosphorylation Monoatomic Cation Channel Activity Regulation Of Monoatomic Ion Transport Sodium Channel Activity Regulation Of Muscle Contraction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Membrane Potential Cell Projection Cardiac Muscle Contraction Membrane Invagination Sphingolipid Floppase Activity Regulation Of Heart Contraction Positive Regulation Of Epithelial Cell Proliferation Establishment Of Planar Polarity Involved In Nephron Morphogenesis T-tubule	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Neuromuscular Junction Anchoring Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Dystrophin-associated Glycoprotein Complex Ionotropic Glutamate Receptor Binding Plasma Membrane Receptor Localization To Synapse Receptor Clustering Phosphatase Binding Protein Localization To Synapse Basolateral Plasma Membrane Regulation Of Sodium Ion Transport GMP Kinase Activity PDZ Domain Binding Protein Localization To Cell Junction GDP Metabolic Process Protein Localization To Membrane Kinase Binding Postsynaptic Density Membrane Regulation Of Metal Ion Transport Sarcolemma Bicellular Tight Junction Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Protein Kinase Binding Regulation Of Cardiac Muscle Cell Action Potential GMP Metabolic Process Structural Molecule Activity Regulation Of Biological Quality Adherens Junction Localization Within Membrane Calmodulin Binding Regulation Of Heart Contraction Cell Junction Muscle Contraction Regulation Of System Process Regulation Of Sodium Ion Transmembrane Transport Regulation Of Blood Circulation Sperm Midpiece Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Tight Junction Assembly Tight Junction Organization Regulation Of Action Potential
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