SNTB2 and ERBB4

Number of citations of the paper that reports this interaction (PMID 10725395)
52

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		SNTB2	ERBB4
Gene Name		syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	erb-b2 receptor tyrosine kinase 4
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Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Transport Vesicle Membrane Protein Complex Synapse Extracellular Vesicular Exosome	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Actin Binding Protein Binding Calmodulin Binding Poly(A) RNA Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process		Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)
Protein-Protein Interactions		15 interactors: ABCA1 ADRA1D BAI1 DGKZ DMD DTNA ERBB4 KCNJ12 MAST1 MAST2 PTPRN SCN4A SCN5A UBC UTRN	39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1
Entrez ID		6645	2066
HPRD ID		02491	02767
Ensembl ID		ENSG00000168807	ENSG00000178568
Uniprot IDs		Q13425	Q15303
PDB IDs		2VRF	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Signaling Cell Communication Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Cell-cell Signaling Action Potential Striated Muscle Contraction Regulation Of Ion Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transmembrane Transporter Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Positive Regulation Of Sodium Ion Transport Signal Transduction Cellular Response To Stimulus Cardiac Muscle Contraction Positive Regulation Of Cell-matrix Adhesion Regulation Of Membrane Potential Transmission Of Nerve Impulse Cardiac Muscle Tissue Regeneration Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Heart Contraction Peptide Secretion Blood Circulation Positive Regulation Of Transport Ion Transmembrane Transport Mitotic G1 DNA Damage Checkpoint Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Striated Muscle Contraction Central Nervous System Morphogenesis Establishment Of Glial Blood-brain Barrier Dense Core Granule Maturation Cell Projection Morphogenesis Cell Surface Receptor Signaling Pathway Peptide Transport Movement Of Cell Or Subcellular Component Mitotic DNA Damage Checkpoint Cell Part Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Peptidyl-cysteine S-nitrosylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade
Tagcloud ?		adp cleaved clonogenic concomitantly degs discovering ebp elucidating exhibiting fractionated grp78 h1299 h2ax h460 h460r helpful ionizing ir metalloproteinase organelles overcome parental radioresistance radioresistant ribose scattering syntrophin vesicular zymography	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Difference) ?		adp cleaved clonogenic concomitantly degs discovering ebp elucidating exhibiting fractionated grp78 h1299 h2ax h460 h460r helpful ionizing ir metalloproteinase organelles overcome parental radioresistance radioresistant ribose scattering syntrophin vesicular zymography	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Intersection) ?