SNRPF and IKZF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SNRPF	IKZF1
Description		small nuclear ribonucleoprotein polypeptide F	IKAROS family zinc finger 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription
Pathways		SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Vitamin C levels ( 33203707)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088 29296818) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 23512250 25310577 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29296818 29632299) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) Asthma ( 32296059) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Height ( 28552196) Hemoglobin ( 32888494) Hemoglobin levels ( 28017375) hemolysis of donated blood (osmotic) ( 34014839) High density lipoprotein cholesterol levels ( 29403010 33339817) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 19862010 27863252 28017375 28453575 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 19838195 23273568 26502338 26663301 27399966 28714469) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010 33339817) Type 1 diabetes ( 25751624)
Interacting Genes		30 interacting genes: CEBPA COIL CPSF7 DDX20 FOXP1 GEMIN5 GEMIN6 HOMER3 HSPB1 IKZF1 IL7R LNX1 LSM3 LSM5 LSM6 LSM7 MEOX2 OSBPL2 POLDIP3 PRPF6 PSMA3 PUF60 RPL9 SMN2 SNRPD2 SNRPE SNRPG SRRT SRSF5 WDR77	107 interacting genes: AEN AIRIM ALKBH3 ANKRD11 ANKRD36 AP1M1 AP2M1 ARMC7 ATOSB BARD1 BYSL C1orf174 C8orf33 CBX8 CCDC185 CDC7 CDK2AP2 CDKL3 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CWF19L2 DCX DDB1 DDX6 DYRK2 FAM161A FAM50B FAM74A4 FGF12 FHL2 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO1 LMO2 LMO3 LMO4 LSM4 MAD2L2 MAGOHB MAPRE3 MCRS1 MEOX2 MORF4L1 MORF4L2 MOS MPPED2 NEK6 NME7 NOC4L NUDT21 PIAS2 PIN1 PNKP PPL PRKAA2 PRKAB2 PRPF18 PSMA1 PSMA4 QARS1 RAD51D RBBP8 RBM43 RNF4 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPA1 SNRPF SNW1 SPATC1L SYT17 TBP TCEA2 TDG TSTD2 TXK UBE2I USP7 ZMAT2 ZNF417 ZNF580 ZNF581 ZNF587
Entrez ID		6636	10320
HPRD ID		04645	04318
Ensembl ID		ENSG00000139343	ENSG00000185811
Uniprot IDs		P62306	A0A2R8Y4D3 A0A2R8YFR0 A0A8V8TNQ0 C9JTB0 Q13422 R9R4D9
PDB IDs		3CW1 3JCR 3PGW 4F7U 4PJO 4V98 4WZJ 5MQF 5O9Z 5XJC 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL	6H0F 8D7Z 8D80 8RQC 8TNP 8TNQ 8TNR
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Protein-RNA Complex Assembly SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex MRNA Metabolic Process U2-type Precatalytic Spliceosome MRNA Splicing, Via Spliceosome RNA Processing RNA Binding Nucleoplasm Spliceosomal Complex Assembly RNA Metabolic Process Lsm2-8 Complex Ribonucleoprotein Complex Spliceosomal Complex U6 SnRNP SMN Complex Gemini Of Cajal Bodies Methylosome Protein-containing Complex Assembly Catalytic Step 2 Spliceosome Nucleus Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome Protein-containing Complex Organization U5 SnRNP Lsm1-7-Pat1 Complex Nucleic Acid Metabolic Process U12-type Spliceosomal Complex 7-methylguanosine Cap Hypermethylation U4 SnRNP Nucleobase-containing Compound Metabolic Process Cellular Component Assembly U1 SnRNP Macromolecule Metabolic Process Cytosol U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Nuclear Body PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U7 SnRNP Regulation Of Gene Expression U1 SnRNA Binding Regulation Of Macromolecule Biosynthetic Process	Nucleoplasm Nucleus DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein Binding Sin3-type Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Androgen Receptor Signaling Pathway Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process NuRD Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process PML Body Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Cell Fate Specification Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA Metabolic Process Nuclear Speck U2-type Precatalytic Spliceosome Chromatin Organization RNA Splicing Negative Regulation Of Metabolic Process Protein K6-linked Ubiquitination DNA Repair
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?