SNRPF and OSBPL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNRPF	OSBPL2
Description		small nuclear ribonucleoprotein polypeptide F	oxysterol binding protein like 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Perinuclear Endoplasmic Reticulum Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Sterol Transfer Activity Cholesterol Transfer Activity
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly	Bile Acid Biosynthetic Process Lipid Transport Plasma Membrane Organization Regulation Of Synaptic Vesicle Priming Phospholipid Transport Cholesterol Transport Intracellular Cholesterol Transport Protein Homotetramerization Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Intermembrane Lipid Transfer
Pathways		SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	Synthesis of bile acids and bile salts
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Vitamin C levels ( 33203707)	Bipolar disorder ( 34002096) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lumbar spine bone mineral density ( 29499414) Nicotine dependence symptom count ( 25555482) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		30 interacting genes: CEBPA COIL CPSF7 DDX20 FOXP1 GEMIN5 GEMIN6 HOMER3 HSPB1 IKZF1 IL7R LNX1 LSM3 LSM5 LSM6 LSM7 MEOX2 OSBPL2 POLDIP3 PRPF6 PSMA3 PUF60 RPL9 SMN2 SNRPD2 SNRPE SNRPG SRRT SRSF5 WDR77	4 interacting genes: SNAP25 SNRPF UBC VAPB
Entrez ID		6636	9885
HPRD ID		04645	09473
Ensembl ID		ENSG00000139343	ENSG00000130703
Uniprot IDs		P62306	A0A2R8YDU7 B4DKJ8 E7ET92 Q9H1P3
PDB IDs		3CW1 3JCR 3PGW 4F7U 4PJO 4V98 4WZJ 5MQF 5O9Z 5XJC 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL	5ZM8
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Protein-RNA Complex Assembly SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex MRNA Metabolic Process U2-type Precatalytic Spliceosome MRNA Splicing, Via Spliceosome RNA Processing RNA Binding Nucleoplasm Spliceosomal Complex Assembly RNA Metabolic Process Lsm2-8 Complex Ribonucleoprotein Complex Spliceosomal Complex U6 SnRNP SMN Complex Gemini Of Cajal Bodies Methylosome Protein-containing Complex Assembly Catalytic Step 2 Spliceosome Nucleus Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome Protein-containing Complex Organization U5 SnRNP Lsm1-7-Pat1 Complex Nucleic Acid Metabolic Process U12-type Spliceosomal Complex 7-methylguanosine Cap Hypermethylation U4 SnRNP Nucleobase-containing Compound Metabolic Process Cellular Component Assembly U1 SnRNP Macromolecule Metabolic Process Cytosol U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Nuclear Body PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U7 SnRNP Regulation Of Gene Expression U1 SnRNA Binding Regulation Of Macromolecule Biosynthetic Process	Membrane Docking Organelle Localization By Membrane Tethering Vesicle Organization Ribbon Synapse Vesicle Dense Core Granule Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Fusion To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Neuronal Dense Core Vesicle Exocytosis U4 SnRNP U7 SnRNP PICln-Sm Protein Complex 7-methylguanosine Cap Hypermethylation Endoplasmic Reticulum Localization FFAT Motif Binding Host-mediated Activation Of Viral Genome Replication COPII-coated Vesicle Budding Negative Regulation By Virus Of Viral Protein Levels In Host Cell IRE1-mediated Unfolded Protein Response Endoplasmic Reticulum-plasma Membrane Tethering Host-mediated Perturbation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Synaptic Vesicle Docking Somatodendritic Compartment Synaptic Vesicle Membrane Organization BLOC-1 Complex Synaptic Vesicle Priming SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Methylosome Protein Tag Activity Suppression Of Viral Release By Host Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Genome Replication Organelle Localization Syntaxin-1 Binding U1 SnRNP Secretory Granule Localization U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Glutamatergic Synapse Neurotransmitter Uptake U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U2 SnRNP Viral Release From Host Cell
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