SNRPF and PRPF6

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SNRPF	PRPF6
Description		small nuclear ribonucleoprotein polypeptide F	pre-mRNA processing factor 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Centrosome Cytosol Membrane Nuclear Speck Ciliary Basal Body U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Localization RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Vitamin C levels ( 33203707)	Body mass index ( 28552196) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		30 interacting genes: CEBPA COIL CPSF7 DDX20 FOXP1 GEMIN5 GEMIN6 HOMER3 HSPB1 IKZF1 IL7R LNX1 LSM3 LSM5 LSM6 LSM7 MEOX2 OSBPL2 POLDIP3 PRPF6 PSMA3 PUF60 RPL9 SMN2 SNRPD2 SNRPE SNRPG SRRT SRSF5 WDR77	67 interacting genes: AR ARAF BAG4 BICD2 C1orf35 CD2BP2 CEBPA CEP55 CLK2 CPSF7 CTBP1 CTTN DDX17 DMRTB1 EFTUD2 EHMT2 ESR1 EXOSC7 EXOSC8 FHIT FXR2 HNRNPLL HOOK1 IDH3A KIF24 KRT31 LARP4 LMNA MRPL1 MRPL44 MRPS11 NIN NME1 NR3C1 PCM1 PHF5A PPIE QKI RAF1 RBM22 RBPMS RNF10 RPL36AL RYBP SF3B4 SMARCA2 SNRNP200 SNRNP48 SNRNP70 SNRPA SNRPF SRRM2 SRSF2 SRSF8 SUMO2 SUN2 TFIP11 THOC1 TIMM44 TRAK1 TRMT1L TSNAXIP1 TXNL4B USO1 VIM YWHAB ZRSR2
Entrez ID		6636	24148
HPRD ID		04645	10729
Ensembl ID		ENSG00000139343	ENSG00000101161
Uniprot IDs		P62306	O94906
PDB IDs		3CW1 3JCR 3PGW 4F7U 4PJO 4V98 4WZJ 5MQF 5O9Z 5XJC 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Protein-RNA Complex Assembly SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex MRNA Metabolic Process U2-type Precatalytic Spliceosome MRNA Splicing, Via Spliceosome RNA Processing RNA Binding Nucleoplasm Spliceosomal Complex Assembly RNA Metabolic Process Lsm2-8 Complex Ribonucleoprotein Complex Spliceosomal Complex U6 SnRNP SMN Complex Gemini Of Cajal Bodies Methylosome Protein-containing Complex Assembly Catalytic Step 2 Spliceosome Nucleus Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome Protein-containing Complex Organization U5 SnRNP Lsm1-7-Pat1 Complex Nucleic Acid Metabolic Process U12-type Spliceosomal Complex 7-methylguanosine Cap Hypermethylation U4 SnRNP Nucleobase-containing Compound Metabolic Process Cellular Component Assembly U1 SnRNP Macromolecule Metabolic Process Cytosol U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Nuclear Body PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U7 SnRNP Regulation Of Gene Expression U1 SnRNA Binding Regulation Of Macromolecule Biosynthetic Process	RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Metabolic Process Nucleic Acid Binding Nuclear Speck Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Regulation Of RNA Splicing U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Protein Binding Identical Protein Binding U2-type Catalytic Step 2 Spliceosome U5 SnRNP Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Estrogen Response Element Binding Regulation Of MRNA Processing Microtubule Anchoring At Microtubule Organizing Center Spliceosomal Complex Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing U1 SnRNP Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Microtubule Anchoring U2-type Prespliceosome Assembly Protein-RNA Complex Assembly Nuclear Migration Regulation Of Alternative MRNA Splicing, Via Spliceosome U2 SnRNP Nuclear Matrix Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2-type Spliceosomal Complex Steroid Hormone Receptor Signaling Pathway
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