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GLMN and FKBP1A
Number of citations of the paper that reports this interaction (PMID
8955134
)
14
Data Source:
HPRD
(in vitro, in vivo)
GLMN
FKBP1A
Gene Name
glomulin, FKBP associated protein
FK506 binding protein 1A, 12kDa
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Terminal Cisterna
Membrane
Z Disc
Sarcoplasmic Reticulum Membrane
Axon Terminus
Extracellular Vesicular Exosome
Molecular Function
Hepatocyte Growth Factor Receptor Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Inhibitor Activity
Peptidyl-prolyl Cis-trans Isomerase Activity
Signal Transducer Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Macrolide Binding
FK506 Binding
Calcium Channel Inhibitor Activity
Enzyme Binding
Hsp70 Protein Binding
Type I Transforming Growth Factor Beta Receptor Binding
Protein Homodimerization Activity
Ion Channel Binding
SMAD Binding
Activin Binding
Biological Process
Vasculogenesis
Neural Tube Closure
Negative Regulation Of Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Phosphorylation
Muscle Cell Differentiation
Positive Regulation Of Interleukin-2 Biosynthetic Process
Positive Regulation Of Cytokine Secretion
Protein Peptidyl-prolyl Isomerization
Negative Regulation Of Protein Phosphorylation
Heart Morphogenesis
Protein Folding
'de Novo' Protein Folding
Muscle Contraction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Response To Iron Ion
Cytokine-mediated Signaling Pathway
Protein Maturation By Protein Folding
Response To Caffeine
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Binding
Negative Regulation Of Protein Phosphatase Type 2B Activity
Regulation Of Protein Localization
Regulation Of Activin Receptor Signaling Pathway
Protein Refolding
T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Extracellular Fibril Organization
Regulation Of Immune Response
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Heart Trabecula Formation
Chaperone-mediated Protein Folding
Calcium Ion Transmembrane Transport
Regulation Of Amyloid Precursor Protein Catabolic Process
Amyloid Fibril Formation
Pathways
Loss of Function of TGFBR2 in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Pimecrolimus
Tacrolimus
Sirolimus
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
Gpi-1046
Methyl Methylsulfinylmethyl Sulfide
FKB-001
Heptyl-Beta-D-Glucopyranoside
L-709,587
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
4-Hydroxy-2-Butanone
MYRISTIC ACID
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
CUL1
FBXW7
FKBP1A
FKBP4
MET
NSFL1C
RBX1
RNF7
SKP1
21 interactors:
ACVR1B
ACVRL1
AHSP
APP
BARD1
BMPR1A
DHFR
FKBP4
GLMN
ITPR1
MID1
MTOR
PPP3CA
RYR1
RYR3
SF3B4
TGFB1
TGFB1I1
TGFBR1
TRPC3
YY1
Entrez ID
11146
2280
HPRD ID
03451
01741
Ensembl ID
ENSG00000174842
ENSG00000088832
Uniprot IDs
B4DJ85
Q92990
P62942
Q0VDC6
PDB IDs
4F52
1A7X
1B6C
1BKF
1BL4
1D6O
1D7H
1D7I
1D7J
1EYM
1F40
1FAP
1FKB
1FKD
1FKF
1FKG
1FKH
1FKI
1FKJ
1FKR
1FKS
1FKT
1J4H
1J4I
1J4R
1NSG
1QPF
1QPL
2DG3
2DG4
2DG9
2FAP
2FKE
2PPN
2PPO
2PPP
2RSE
3FAP
3H9R
3MDY
4DH0
4FAP
4IPX
Enriched GO Terms of Interacting Partners
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SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Notch Signaling Pathway
Cellular Protein Metabolic Process
Protein Monoubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Modification Process
Protein Ubiquitination
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Metabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Cell Communication
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Neddylation
Cellular Macromolecule Catabolic Process
Positive Regulation Of Protein Modification Process
Cellular Response To Stimulus
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Viral Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Protein Metabolic Process
Signal Transduction
Positive Regulation Of Protein Catabolic Process
Regulation Of Catalytic Activity
Response To Stimulus
Signaling
Cellular Response To Stress
Proteolysis
Positive Regulation Of Proteolysis
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Catabolic Process
Chaperone-mediated Protein Folding
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Cell Surface Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
Response To Organic Substance
Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Transport
Developmental Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Multicellular Organismal Development
Regulation Of Phosphorylation
Regulation Of Establishment Of Protein Localization
Regulation Of Intracellular Transport
Response To Stress
Regulation Of Intracellular Protein Transport
Regulation Of Cellular Localization
Response To Abiotic Stimulus
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Protein Localization
Positive Regulation Of SMAD Protein Import Into Nucleus
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Phosphorylation
Regulation Of SMAD Protein Import Into Nucleus
Positive Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Regulation Of Protein Localization To Nucleus
Cell Differentiation
Regulation Of Gene Expression
Anatomical Structure Development
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Cellular Response To Organic Substance
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Intracellular Transport
Response To Stimulus
Negative Regulation Of Cell Differentiation
Activin Receptor Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Cell Differentiation
Signal Transduction By Phosphorylation
Regulation Of Metabolic Process
Regulation Of Epithelial Cell Proliferation
Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Cellular Chemical Homeostasis
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