GLMN and FKBP4

Number of citations of the paper that reports this interaction (PMID 8955134)
14

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		GLMN	FKBP4
Gene Name		glomulin, FKBP associated protein	FK506 binding protein 4, 59kDa
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Gene Ontology Annotations	Cellular Component	Intracellular Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Microtubule Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Hepatocyte Growth Factor Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Inhibitor Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding ATP Binding GTP Binding FK506 Binding Protein Binding, Bridging Heat Shock Protein Binding Copper-dependent Protein Binding Glucocorticoid Receptor Binding Poly(A) RNA Binding Tau Protein Binding Phosphoprotein Binding
	Biological Process	Vasculogenesis Neural Tube Closure Negative Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of T Cell Proliferation Positive Regulation Of Phosphorylation Muscle Cell Differentiation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Cytokine Secretion	Protein Peptidyl-prolyl Isomerization Protein Folding Steroid Hormone Receptor Complex Assembly Copper Ion Transport Embryo Implantation Negative Regulation Of Neuron Projection Development Androgen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Protein Complex Localization Cellular Response To Heat Male Sex Differentiation Chaperone-mediated Protein Folding Regulation Of Cellular Response To Heat
Pathways			HSF1-dependent transactivation Attenuation phase Cellular response to heat stress
Drugs
Diseases
GWAS			Quantitative traits ( 19197348)
Protein-Protein Interactions		9 interactors: CUL1 FBXW7 FKBP1A FKBP4 MET NSFL1C RBX1 RNF7 SKP1	25 interactors: ACVR1 ATOX1 CALM1 CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSP90AA1 HSPA4 IRF4 NR3C1 NR3C2 PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2 SNCA SQSTM1 STIP1
Entrez ID		11146	2288
HPRD ID		03451	11794
Ensembl ID		ENSG00000174842
Uniprot IDs		B4DJ85 Q92990	Q02790
PDB IDs		4F52	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX
Enriched GO Terms of Interacting Partners?		SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Cellular Protein Metabolic Process Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cell Communication Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Viral Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Response To Stimulus Signaling Cellular Response To Stress Proteolysis Positive Regulation Of Proteolysis Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Catabolic Process Chaperone-mediated Protein Folding Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process	Response To Organic Substance Cellular Response To Organic Substance Regulation Of Oxidoreductase Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Nitric-oxide Synthase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Lipid Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Response To Organic Cyclic Compound Response To Growth Factor Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Developmental Process System Development Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Cyclic Compound Signaling Regulation Of Signaling Regulation Of Immune System Process Cell Communication Defense Response Protein Import Into Mitochondrial Outer Membrane Response To Steroid Hormone Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Oxidoreductase Activity Response To Stress Regulation Of Cell Proliferation Positive Regulation Of Nitric Oxide Biosynthetic Process Multicellular Organismal Development Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Innate Immune Response Cellular Response To Glucocorticoid Stimulus Response To Glucocorticoid Anatomical Structure Development Cellular Response To Corticosteroid Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Immune Response Response To Corticosteroid
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