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SUMO2 and SIRT1
Number of citations of the paper that reports this interaction (PubMedID
30201799
)
46
Data Source:
BioGRID
(enzymatic study)
SUMO2
SIRT1
Description
small ubiquitin like modifier 2
sirtuin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
PML Body
Hippocampal Mossy Fiber To CA3 Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
GABA-ergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Chromosome, Telomeric Region
Chromatin
Euchromatin
Heterochromatin
Fibrillar Center
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Chromatin Silencing Complex
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
PML Body
Protein-containing Complex
RDNA Heterochromatin
ESC/E(Z) Complex
ENoSc Complex
Molecular Function
RNA Binding
Protein Binding
SUMO Transferase Activity
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-like Protein Ligase Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
NAD+ Poly-ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Enzyme Inhibitor Activity
Protein Binding
Enzyme Activator Activity
Transferase Activity
Nuclear Receptor Binding
Histone Deacetylase Activity, NAD-dependent
Deacetylase Activity
Enzyme Binding
Protein Domain Specific Binding
Histone H3K14 Deacetylase Activity, NAD-dependent
Protein Lysine Deacetylase Activity
NAD-dependent Protein Lysine Deacetylase Activity
Histone Binding
Identical Protein Binding
HLH Domain Binding
BHLH Transcription Factor Binding
Metal Ion Binding
Histone H3K9 Deacetylase Activity, NAD-dependent
Histone H4K16 Deacetylase Activity, NAD-dependent
Mitogen-activated Protein Kinase Binding
NAD+ Binding
NAD-dependent Protein-lysine Depropionylase Activity
DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism
Histone H3K Deacetylase Activity
NAD-dependent Protein Lysine Delactylase Activity
NAD-dependent Protein Decrotonylase Activity
Histone Decrotonylase Activity, NAD-dependent
Keratin Filament Binding
NAD+-protein Mono-ADP-ribosyltransferase Activity
Promoter-specific Chromatin Binding
Biological Process
Protein Sumoylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Single Strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Formation
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Synthesis Involved In DNA Repair
Angiogenesis
Ovulation From Ovarian Follicle
Intracellular Glucose Homeostasis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Adaptive Immune Response
Gluconeogenesis
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
Protein Deacetylation
Triglyceride Mobilization
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Muscle Organ Development
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cellular Response To Starvation
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Negative Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Regulation Of Glucose Metabolic Process
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Peptidyl-lysine Acetylation
Triglyceride Biosynthetic Process
Cell Differentiation
Macrophage Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Prostaglandin Biosynthetic Process
Heterochromatin Formation
Subtelomeric Heterochromatin Formation
Protein Destabilization
Negative Regulation Of TOR Signaling
Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Insulin
Circadian Regulation Of Gene Expression
Leptin-mediated Signaling Pathway
Regulation Of Smooth Muscle Cell Apoptotic Process
Hippo Signaling
Negative Regulation Of Hippo Signaling
Intracellular Triglyceride Homeostasis
Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Cellular Response To Glucose Starvation
Negative Regulation Of Phosphorylation
Response To Hydrogen Peroxide
Behavioral Response To Starvation
Cholesterol Homeostasis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Leptin
Positive Regulation Of MHC Class II Biosynthetic Process
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By Glucose
Positive Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Lipid Biosynthetic Process
Rhythmic Process
Regulation Of Developmental Process
White Fat Cell Differentiation
Positive Regulation Of Smooth Muscle Cell Differentiation
Regulation Of Multicellular Organismal Process
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Maintenance Of Nucleus Location
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Fatty Acid Homeostasis
Negative Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of Small Molecule Metabolic Process
Cellular Response To Hydrogen Peroxide
Regulation Of Bile Acid Biosynthetic Process
UV-damage Excision Repair
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Signal Transduction By P53 Class Mediator
Tricarboxylic Acid Metabolic Process
Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Energy Homeostasis
Protein Depropionylation
DNA Repair-dependent Chromatin Remodeling
Regulation Of Cellular Response To Heat
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Protein Acetylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Positive Regulation Of Adipose Tissue Development
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Cellular Response To Testosterone Stimulus
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair
Pathways
Vitamin D (calciferol) metabolism
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of HSF1-mediated heat shock response
SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Heme signaling
Negative Regulation of CDH1 Gene Transcription
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of MITF-M dependent genes involved in metabolism
Transcriptional and post-translational regulation of MITF-M expression and activity
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs
Resveratrol
Selisistat
Cambinol
Diseases
GWAS
Deep white matter hyperintensities (
32517579
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Serum metabolite levels (
33031748
)
Type 2 diabetes (
32499647
)
Atrial fibrillation (
30061737
)
Chronotype (
30696823
)
Diverticular disease (
30177863
)
Molybdenum levels (
26025379
)
Pulse pressure (
30224653
)
Interacting Genes
459 interacting genes:
AARS1
ABCF1
ABRAXAS1
ACIN1
ACTB
AFG2A
AFG2B
AHCYL1
AHNAK
AHNAK2
AIMP1
ALAS1
ANAPC1
ANAPC2
ANLN
ANXA1
APRT
ARF3
ARF4
ARID2
ARK2N
ARRB2
ASNS
ASS1
ATF7IP
ATRX
ATXN7
BABAM2
BAD
BAZ1A
BAZ1B
BLM
BOD1L1
BPTF
BRCC3
BZW1
CAD
CALM1
CARS1
CAST
CCAR2
CCNE2
CCT2
CCT3
CCT4
CCT5
CCT6A
CDK2
CEBPA
CENPC
CHAF1A
CHAF1B
CHAMP1
CHD3
CHD4
CHD8
CKAP5
CLTC
CMTM6
COPA
COPB2
COPG1
CPSF2
CPSF7
CSE1L
CSNK2B
CTNNBL1
CTNND1
CTR9
CUL3
CUX1
DAB2
DARS1
DAXX
DCD
DDX1
DDX17
DDX21
DDX39A
DDX3X
DDX5
DIDO1
DIP2B
DNAJA1
DNM1L
DNMT1
DYNC1H1
EDC4
EEF1A1
EEF1A2
EEF1G
EEF2
EFTUD2
EGLN3
EHD4
EHMT1
EIF4A1
EIF4A2
EIF4G1
EIF4G2
EIF5A
ELAC2
EME1
EMG1
EML3
ENO1
EP300
EP400
EPPK1
EPRS1
ERCC4
ERCC6
EXOSC10
EXOSC9
EZR
FARSB
FASN
FBXO38
FLNA
FLNB
FOS
GALK1
GAPVD1
GATAD2B
GCN1
GEMIN5
GPATCH8
GTF2I
GTF3C1
GTF3C2
GTF3C4
GYS1
HCFC1
HDAC1
HDAC2
HDAC4
HDAC9
HDLBP
HIPK2
HK2
HMGXB4
HNRNPA0
HNRNPA1L2
HNRNPA2B1
HNRNPF
HNRNPH1
HNRNPH2
HNRNPK
HNRNPL
HNRNPLL
HNRNPM
HNRNPR
HNRNPU
HOMEZ
HP1BP3
HPS6
HSF2
HSP90AA1
HSP90AB1
HSPA1A
HSPA5
HSPA8
HSPA9
HSPB1
HSPD1
HUWE1
IARS1
ILK
IMPDH2
INTS3
IPO5
IQGAP1
JUN
KALRN
KARS1
KDM1A
KDM5C
KIF11
KIF18B
KIF23
KIF2A
KIF2C
KIF4A
KIF5B
KPNA2
KRT8
LARS1
LAS1L
LEF1
LMNA
LMO7
MAF1
MAP4
MARS1
MAST2
MCM3
MCM4
MDC1
MDN1
MKI67
MMS19
MORC3
MPI
MRE11
MSH2
MSH3
MSH6
MSX1
MTA1
MTA2
MTHFD1
MUS81
MYB
MYG1
NAP1L1
NARS1
NAT10
NBN
NCAPD2
NCAPD3
NCAPG
NCAPH2
NCL
NCOR1
NFATC2IP
NFE2L2
NIBAN2
NIPBL
NOL9
NONO
NOP2
NPM1
NSUN2
NUMA1
NUP107
NUP160
NUP214
ORC3
P4HA1
P4HB
PAF1
PALLD
PARN
PARP1
PBRM1
PCBP2
PDCD4
PDCD6IP
PDS5A
PELP1
PFKL
PFKM
PFKP
PGK1
PHF3
PHF5A
PHF8
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PKN2
PLEC
PML
POGZ
POLA1
POLD1
POLR2A
PPIE
PPP1CC
PPP2R1A
PRC1
PRDX6
PRKDC
PRPF6
PRPF8
PSMC1
PSMC3
PSMC4
PSMC5
PTBP1
RAD21
RAD50
RAD51
RAD54L2
RAN
RANBP2
RANGAP1
RARS1
RBBP4
RBBP7
RCC1
RCOR1
RCOR2
RCOR3
RFC2
RFC4
RFC5
RIF1
RNF111
RNF168
RNF20
RNF213
RNF216
RNF4
RNF8
RPL10
RPL3
RPL4
RPS3
RPS4X
RPS6KA3
RREB1
RRM1
RUVBL1
S100A10
SAE1
SAFB
SAFB2
SALL1
SAMHD1
SARS1
SART1
SCAF11
SENP1
SENP2
SENP3
SENP5
SENP6
SENP7
SERPINB6
SETDB1
SETX
SF3A1
SF3B1
SF3B2
SIMC1
SIN3A
SIRT1
SLC22A2
SLX4IP
SMARCA4
SMARCAD1
SMC1A
SMC3
SMC4
SMCHD1
SND1
SNRNP200
SNW1
SNX27
SOBP
SOX10
SOX6
SP1
SP100
SPR
SPTAN1
SPTBN1
SRCAP
SRP68
SRRM2
SRRT
SSRP1
STAG2
STIP1
STRAP
SUPT16H
SUPT5H
SYMPK
SYNCRIP
TAF1
TAGLN2
TCERG1
TCP1
TDG
TDP2
TEAD3
TEX10
TK1
TLN1
TMPO
TNIP1
TOP2A
TOP2B
TOPORS
TP53BP1
TP53BP2
TPR
TPX2
TRAF1
TRIM25
TRIM26
TRIM28
TRIM63
TRIML2
TRIP13
TRMT1L
TSR1
TTI1
TTLL12
TUBA1B
TUBA1C
TUBA4A
TUBB
TUBB4A
TUBB4B
TUBB6
U2AF2
UBA1
UBA2
UBAP2L
UBE2I
UBR4
UIMC1
UMPS
UPF1
USP11
USP25
USP28
USP36
USP48
USP5
USP7
USP9X
USPL1
VARS1
VIM
WAPL
WASHC2C
WDHD1
WRN
XAB2
XPNPEP1
XPO1
XPO5
XRCC5
XRCC6
YWHAQ
ZBED1
ZBTB2
ZBTB25
ZBTB33
ZBTB39
ZC3H11A
ZCCHC12
ZCCHC7
ZHX1
ZMAT3
ZMIZ2
ZMYM2
ZMYM3
ZMYM4
ZMYM5
ZMYND8
ZNF451
ZNF496
ZNF638
69 interacting genes:
AFP
AKT1
AR
BAZ1B
BCL11A
BHLHE41
BMAL1
BRIP1
CCAR2
CDK2
CDK6
CENATAC
CHFR
CLOCK
CTTN
CUL4B
E2F1
EP300
ESRRA
EZH2
FOS
FOXM1
FOXO1
FOXO3
FZR1
GAPDH
H1-5
H3C1
HES1
HEY2
HIC1
HIPK2
HNF4A
HOXB9
MAPK8
MCL1
MPHOSPH8
MYCN
NBN
NDN
NEDD8
NMNAT1
NR1H2
NR1H3
NR1H4
PML
PPARA
PPARG
PPARGC1A
PRMT1
PSME3
RARA
RELA
RICTOR
RPS19BP1
RRP8
SATB1
SETD7
SMAD7
SNW1
SOX2-OT
STK11
STK4
SUMO2
TP53
TP73
TRIM28
UBE2I
VDR
Entrez ID
6613
23411
HPRD ID
04332
08381
Ensembl ID
ENSG00000188612
ENSG00000096717
Uniprot IDs
P61956
A8K128
B0QZ35
E9PC49
Q96EB6
PDB IDs
1WM2
1WM3
1WZ0
2AWT
2CKH
2D07
2IO0
2IO3
2IYD
2N1W
2N9E
2RPQ
3UIN
3UIO
3ZO5
4BKG
4NPN
5D2M
5ELU
5EQL
5GHB
5GHC
6JXW
6JXX
7ZJV
4I5I
4IF6
4IG9
4KXQ
4ZZH
4ZZI
4ZZJ
5BTR
8ANB
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Nucleic Acid Metabolic Process
RNA Binding
Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
DNA Metabolic Process
DNA Repair
ATP Hydrolysis Activity
Regulation Of Metabolic Process
DNA Damage Response
ATP Binding
Nucleotide Binding
Cellular Response To Stress
Cytosol
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Regulation Of DNA Metabolic Process
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Chromatin Organization
Chromosome
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleolus
Cytoplasm
Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Chromatin Remodeling
Chromatin Binding
Positive Regulation Of Metabolic Process
Regulation Of Chromosome Organization
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Chromosome Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA Metabolic Process
Double-strand Break Repair
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Chromatin
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Sequence-specific DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Biosynthetic Process
DNA Damage Response
DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Signal Transduction By P53 Class Mediator
Nuclear Receptor Activity
Negative Regulation Of Developmental Process
Intracellular Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Macromolecule Metabolic Process
Regulation Of Cell Differentiation
Chromatin DNA Binding
Rhythmic Process
Regulation Of Developmental Process
Regulation Of Cell Cycle
Tagcloud
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Tagcloud (Intersection)
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