SUMO2 and CPSF2

Number of citations: 0 (PubMedID 32786267)
Data Source: BioGRID (pull down)

		SUMO2	CPSF2
Name		small ubiquitin like modifier 2	cleavage and polyadenylation specific factor 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding SUMO Transferase Activity Protein Tag Activity Ubiquitin Protein Ligase Binding Ubiquitin-like Protein Ligase Binding	RNA Binding Protein Binding
	Biological Process	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage
Pathways		Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Regulation of endogenous retroelements by KRAB-ZFP proteins	Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
GWAS		Deep white matter hyperintensities ( 32517579 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Serum metabolite levels ( 33031748 ) Type 2 diabetes ( 32499647 )	3-month functional outcome in lacunar ischaemic stroke (modified Rankin score) ( 30796134 ) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818 ) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818 ) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818 ) Dialysis-related mortality ( 21546767 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 18391951 ) LDL cholesterol levels x loop diuretics use interaction ( 31806883 ) Monobrow ( 27182965 ) Myopia ( 27182965 ) Obesity-related traits ( 23251661 ) Refractive error ( 32231278 )
Interacting Genes		459 interacting genes: AARS1 ABCF1 ABRAXAS1 ACIN1 ACTB AFG2A AFG2B AHCYL1 AHNAK AHNAK2 AIMP1 ALAS1 ANAPC1 ANAPC2 ANLN ANXA1 APRT ARF3 ARF4 ARID2 ARK2N ARRB2 ASNS ASS1 ATF7IP ATRX ATXN7 BABAM2 BAD BAZ1A BAZ1B BLM BOD1L1 BPTF BRCC3 BZW1 CAD CALM1 CARS1 CAST CCAR2 CCNE2 CCT2 CCT3 CCT4 CCT5 CCT6A CDK2 CEBPA CENPC CHAF1A CHAF1B CHAMP1 CHD3 CHD4 CHD8 CKAP5 CLTC CMTM6 COPA COPB2 COPG1 CPSF2 CPSF7 CSE1L CSNK2B CTNNBL1 CTNND1 CTR9 CUL3 CUX1 DAB2 DARS1 DAXX DCD DDX1 DDX17 DDX21 DDX39A DDX3X DDX5 DIDO1 DIP2B DNAJA1 DNM1L DNMT1 DYNC1H1 EDC4 EEF1A1 EEF1A2 EEF1G EEF2 EFTUD2 EGLN3 EHD4 EHMT1 EIF4A1 EIF4A2 EIF4G1 EIF4G2 EIF5A ELAC2 EME1 EMG1 EML3 ENO1 EP300 EP400 EPPK1 EPRS1 ERCC4 ERCC6 EXOSC10 EXOSC9 EZR FARSB FASN FBXO38 FLNA FLNB FOS GALK1 GAPVD1 GATAD2B GCN1 GEMIN5 GPATCH8 GTF2I GTF3C1 GTF3C2 GTF3C4 GYS1 HCFC1 HDAC1 HDAC2 HDAC4 HDAC9 HDLBP HIPK2 HK2 HMGXB4 HNRNPA0 HNRNPA1L2 HNRNPA2B1 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPLL HNRNPM HNRNPR HNRNPU HOMEZ HP1BP3 HPS6 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA5 HSPA8 HSPA9 HSPB1 HSPD1 HUWE1 IARS1 ILK IMPDH2 INTS3 IPO5 IQGAP1 JUN KALRN KARS1 KDM1A KDM5C KIF11 KIF18B KIF23 KIF2A KIF2C KIF4A KIF5B KPNA2 KRT8 LARS1 LAS1L LEF1 LMNA LMO7 MAF1 MAP4 MARS1 MAST2 MCM3 MCM4 MDC1 MDN1 MKI67 MMS19 MORC3 MPI MRE11 MSH2 MSH3 MSH6 MSX1 MTA1 MTA2 MTHFD1 MUS81 MYB MYG1 NAP1L1 NARS1 NAT10 NBN NCAPD2 NCAPD3 NCAPG NCAPH2 NCL NCOR1 NFATC2IP NFE2L2 NIBAN2 NIPBL NOL9 NONO NOP2 NPM1 NSUN2 NUMA1 NUP107 NUP160 NUP214 ORC3 P4HA1 P4HB PAF1 PALLD PARN PARP1 PBRM1 PCBP2 PDCD4 PDCD6IP PDS5A PELP1 PFKL PFKM PFKP PGK1 PHF3 PHF5A PHF8 PIAS1 PIAS2 PIAS3 PIAS4 PKM PKN2 PLEC PML POGZ POLA1 POLD1 POLR2A PPIE PPP1CC PPP2R1A PRC1 PRDX6 PRKDC PRPF6 PRPF8 PSMC1 PSMC3 PSMC4 PSMC5 PTBP1 RAD21 RAD50 RAD51 RAD54L2 RAN RANBP2 RANGAP1 RARS1 RBBP4 RBBP7 RCC1 RCOR1 RCOR2 RCOR3 RFC2 RFC4 RFC5 RIF1 RNF111 RNF168 RNF20 RNF213 RNF216 RNF4 RNF8 RPL10 RPL3 RPL4 RPS3 RPS4X RPS6KA3 RREB1 RRM1 RUVBL1 S100A10 SAE1 SAFB SAFB2 SALL1 SAMHD1 SARS1 SART1 SCAF11 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SERPINB6 SETDB1 SETX SF3A1 SF3B1 SF3B2 SIMC1 SIN3A SIRT1 SLC22A2 SLX4IP SMARCA4 SMARCAD1 SMC1A SMC3 SMC4 SMCHD1 SND1 SNRNP200 SNW1 SNX27 SOBP SOX10 SOX6 SP1 SP100 SPR SPTAN1 SPTBN1 SRCAP SRP68 SRRM2 SRRT SSRP1 STAG2 STIP1 STRAP SUPT16H SUPT5H SYMPK SYNCRIP TAF1 TAGLN2 TCERG1 TCP1 TDG TDP2 TEAD3 TEX10 TK1 TLN1 TMPO TNIP1 TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TPR TPX2 TRAF1 TRIM25 TRIM26 TRIM28 TRIM63 TRIML2 TRIP13 TRMT1L TSR1 TTI1 TTLL12 TUBA1B TUBA1C TUBA4A TUBB TUBB4A TUBB4B TUBB6 U2AF2 UBA1 UBA2 UBAP2L UBE2I UBR4 UIMC1 UMPS UPF1 USP11 USP25 USP28 USP36 USP48 USP5 USP7 USP9X USPL1 VARS1 VIM WAPL WASHC2C WDHD1 WRN XAB2 XPNPEP1 XPO1 XPO5 XRCC5 XRCC6 YWHAQ ZBED1 ZBTB2 ZBTB25 ZBTB33 ZBTB39 ZC3H11A ZCCHC12 ZCCHC7 ZHX1 ZMAT3 ZMIZ2 ZMYM2 ZMYM3 ZMYM4 ZMYM5 ZMYND8 ZNF451 ZNF496 ZNF638	13 interacting genes: DLGAP1-AS2 MIR19A MIR19B1 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A3 MIRLET7F2 POLR2A RNF10 SUMO2 UNKL WWOX
Entrez ID		6613	53981
HPRD ID		04332	05824
Ensembl ID		ENSG00000188612	ENSG00000165934
Uniprot IDs		P61956	Q9P2I0
PDB IDs		1WM2 1WM3 1WZ0 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2N1W 2N9E 2RPQ 3UIN 3UIO 3ZO5 4BKG 4NPN 5D2M 5ELU 5EQL 5GHB 5GHC 6JXW 6JXX 7ZJV	6URG 6V4X
GO Terms Enriched among Interactors		Nucleus Nucleoplasm Nucleic Acid Metabolic Process RNA Binding Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Metabolic Process DNA Repair ATP Hydrolysis Activity Regulation Of Metabolic Process DNA Damage Response ATP Binding Nucleotide Binding Cellular Response To Stress Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA Metabolic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Chromosome Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Nucleolus Cytoplasm Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Chromatin Binding Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Metabolic Process Double-strand Break Repair	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Extracellular Vesicle Negative Regulation Of Extracellular Matrix Organization MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Regulation Of Gene Expression Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly Cellular Response To Bacterial Lipopeptide Regulation Of Macromolecule Biosynthetic Process Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration MRNA Destabilization RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Motility Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Locomotion Regulation Of Extracellular Matrix Assembly Regulation Of Macromolecule Metabolic Process Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Interleukin-6 Production Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Translation Negative Regulation Of Striated Muscle Cell Apoptotic Process