NDFIP1 and WEE2-AS1

Number of citations of the paper that reports this interaction (PubMedID 36168628)
47

Data Source:
BioGRID (unspecified method)

		NDFIP1	WEE2-AS1
Description		Nedd4 family interacting protein 1	WEE2 antisense RNA 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cell Cortex Endosome Membrane Membrane Dendrite Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm	U1 SnRNP
	Molecular Function	Protein Binding WW Domain Binding	Pre-mRNA 5'-splice Site Binding
	Biological Process	Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Type 2 Immune Response Ubiquitin-dependent Protein Catabolic Process Intracellular Iron Ion Homeostasis Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Negative Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Transport Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	MRNA 5'-splice Site Recognition
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 34103634 32296059 31959851 31619474 31361310 29273806 22561531 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte count ( 27863252) HDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Low susceptibility to hepatitis C infection ( 31206233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088 31604244 24076602) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Physiological traits ( 31902109) Platelet count ( 27863252 32888494 29403010) Plateletcrit ( 27863252 32888494) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: BDKRB1 CCR2 ITCH NEDD4 NTRK2 PTEN SMO UQCRH WEE2-AS1 WWP2	161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1
Entrez ID		80762	285962
HPRD ID		14816	08286
Ensembl ID		ENSG00000131507	ENSG00000228775
Uniprot IDs		Q9BT67
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Potassium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Forebrain Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Cell Migration Negative Regulation Of Transport Regulation Of Anatomical Structure Morphogenesis Regulation Of Membrane Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Transport Dentate Gyrus Development Regulation Of Biological Quality Negative Regulation Of Potassium Ion Transport Cell Motility Homeostasis Of Number Of Cells Within A Tissue Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Activity Regulation Of Growth Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Receptor Internalization Positive Regulation Of Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Channel Inhibitor Activity Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Potassium Ion Transport Regulation Of Signaling Ubiquitin-protein Transferase Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Protein Metabolic Process Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Regulation Of Developmental Process Brain-derived Neurotrophic Factor Receptor Activity Cerebral Cortex Development Regulation Of Cell Development Vasculogenesis Regulation Of Neurogenesis Regulation Of Cell Differentiation Negative Regulation Of Synaptic Vesicle Clustering	RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization
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