NDFIP1 and BDKRB1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		NDFIP1	BDKRB1
Name		Nedd4 family interacting protein 1	bradykinin receptor B1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cell Cortex Endosome Membrane Membrane Dendrite Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Protein Binding WW Domain Binding	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Type 2 Immune Response Ubiquitin-dependent Protein Catabolic Process Intracellular Iron Ion Homeostasis Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Negative Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Transport Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		None	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		None	Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 30929738 34103634 32296059 31959851 31619474 31361310 29273806 22561531 27182965 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 30929738 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 21102463 28067908 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Granulocyte count ( 27863252 ) HDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429 ) Height ( 31562340 ) Inflammatory bowel disease ( 28067908 23128233 ) Low susceptibility to hepatitis C infection ( 31206233 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 21833088 31604244 24076602 ) Neutrophil count ( 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Physiological traits ( 31902109 ) Platelet count ( 27863252 32888494 29403010 ) Plateletcrit ( 27863252 32888494 ) Squamous cell lung carcinoma ( 28604730 ) Sum eosinophil basophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 )	Metabolite levels ( 23823483 )
Novel Interactors		None recorded	2 novel interactors: DNAJB13 EVL
Interacting Genes		10 interacting genes: BDKRB1 CCR2 ITCH NEDD4 NTRK2 PTEN SMO UQCRH WEE2-AS1 WWP2	32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		80762	623
HPRD ID		14816	02639
Ensembl ID		ENSG00000131507	ENSG00000100739
Uniprot IDs		Q9BT67	P46663
PDB IDs		Not available	7EIB
GO Terms Enriched among Interactors		Protein K63-linked Ubiquitination Potassium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Forebrain Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Cell Migration Negative Regulation Of Transport Regulation Of Anatomical Structure Morphogenesis Regulation Of Membrane Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Transport Dentate Gyrus Development Regulation Of Biological Quality Negative Regulation Of Potassium Ion Transport Cell Motility Homeostasis Of Number Of Cells Within A Tissue Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Activity Regulation Of Growth Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Receptor Internalization Positive Regulation Of Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Channel Inhibitor Activity Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Potassium Ion Transport Regulation Of Signaling Ubiquitin-protein Transferase Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Protein Metabolic Process Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Regulation Of Developmental Process Brain-derived Neurotrophic Factor Receptor Activity Cerebral Cortex Development Regulation Of Cell Development Vasculogenesis Regulation Of Neurogenesis Regulation Of Cell Differentiation Negative Regulation Of Synaptic Vesicle Clustering	Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding