NDFIP1 and UQCRH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NDFIP1	UQCRH
Description		Nedd4 family interacting protein 1	ubiquinol-cytochrome c reductase hinge protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cell Cortex Endosome Membrane Membrane Dendrite Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Protein Binding WW Domain Binding	Protein Binding Quinol-cytochrome-c Reductase Activity
	Biological Process	Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Type 2 Immune Response Ubiquitin-dependent Protein Catabolic Process Intracellular Iron Ion Homeostasis Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Negative Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Transport Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration Proton Transmembrane Transport
Pathways			Respiratory electron transport Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 34103634 32296059 31959851 31619474 31361310 29273806 22561531 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte count ( 27863252) HDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Low susceptibility to hepatitis C infection ( 31206233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088 31604244 24076602) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Physiological traits ( 31902109) Platelet count ( 27863252 32888494 29403010) Plateletcrit ( 27863252 32888494) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)	Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: BDKRB1 CCR2 ITCH NEDD4 NTRK2 PTEN SMO UQCRH WEE2-AS1 WWP2	7 interacting genes: ARL8A ENTREP3 NDFIP1 NDFIP2 NPM1 PRRG1 RNF24
Entrez ID		80762	7388
HPRD ID		14816	15629
Ensembl ID		ENSG00000131507	ENSG00000173660
Uniprot IDs		Q9BT67	P07919 Q567R0
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Potassium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Forebrain Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Cell Migration Negative Regulation Of Transport Regulation Of Anatomical Structure Morphogenesis Regulation Of Membrane Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Transport Dentate Gyrus Development Regulation Of Biological Quality Negative Regulation Of Potassium Ion Transport Cell Motility Homeostasis Of Number Of Cells Within A Tissue Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Activity Regulation Of Growth Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Receptor Internalization Positive Regulation Of Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Channel Inhibitor Activity Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Potassium Ion Transport Regulation Of Signaling Ubiquitin-protein Transferase Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Protein Metabolic Process Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Regulation Of Developmental Process Brain-derived Neurotrophic Factor Receptor Activity Cerebral Cortex Development Regulation Of Cell Development Vasculogenesis Regulation Of Neurogenesis Regulation Of Cell Differentiation Negative Regulation Of Synaptic Vesicle Clustering	WW Domain Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Post-translational Protein Modification Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Protein Modification Process Intracellular Transport Regulation Of Endoribonuclease Activity Negative Regulation Of Protein Transport Negative Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Cellular Localization Regulation Of Protein Modification Process Positive Regulation Of Centrosome Duplication Establishment Of Localization In Cell Membrane Golgi Membrane Negative Regulation Of Establishment Of Protein Localization Vacuolar Transport Negative Regulation Of Isotype Switching Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Granular Component Endosome Negative Regulation Of Interleukin-4 Production Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Tat Protein Binding Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization Ribosomal Subunit Export From Nucleus Negative Regulation Of Centrosome Duplication Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Immunoglobulin Production Spindle Pole Centrosome Ribosomal Large Subunit Binding Endosome Membrane Alpha-beta T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Type 2 Immune Response
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