SMN2 and POLR1C

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SMN2	POLR1C
Gene Name		survival of motor neuron 2, centromeric	polymerase (RNA) I polypeptide C, 30kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Nucleoplasm DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Dimerization Activity
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic
Pathways		snRNP Assembly Metabolism of non-coding RNA	RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Termination NoRC negatively regulates rRNA expression RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Chain Elongation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: BLOC1S6 BYSL CHTOP DDX20 DHX9 FAM9B FBL GAR1 GEMIN2 HNRNPUL1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG TIAL1 VPS28	32 interactors: ATRIP BIRC7 CCDC33 CCDC36 CD3EAP CLU CORO1A CORO1B FAM154A FAM208B IKZF3 KCTD1 KRT19 LZTS2 MBIP MYD88 MYO5B NFKBIB NME1 POLR1D POLR1E POLR2J PPP2R3C RIMBP3 SMN2 TCF4 TNFAIP1 TRIM27 TRIOBP TSC22D4 VIM WRN
Entrez ID		6607	9533
HPRD ID		09036	09661
Ensembl ID		ENSG00000205571	ENSG00000171453
Uniprot IDs		B4DP61 Q16637	O15160
PDB IDs		1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly RNA Splicing RNA Processing MRNA Processing Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process MRNA Metabolic Process Ribonucleoprotein Complex Assembly RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Spliceosomal Complex Assembly Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Termination Cellular Macromolecular Complex Assembly Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing RNA 3'-end Processing Cellular Metabolic Process Cellular Component Assembly Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RRNA Processing RRNA Metabolic Process Metabolic Process Ribosome Biogenesis Histone Glutamine Methylation Cellular Process Transcription, RNA-templated Peptidyl-glutamine Methylation Positive Regulation Of Type I Interferon Production Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway DNA-templated Transcription, Elongation SnoRNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process CRD-mediated MRNA Stabilization Regulation Of Type I Interferon Production Endosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Helicase Activity Secretion Of Lysosomal Enzymes Late Endosome To Vacuole Transport Osteoblast Differentiation	Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Cytoskeleton Organization DNA-templated Transcription, Elongation Cellular Component Assembly Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Response To Stress Actin Filament-based Process Transcription From RNA Polymerase I Promoter Regulation Of Type I Interferon Production Organelle Organization Innate Immune Response Regulation Of Cytokine Production Nucleobase-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Actin Cytoskeleton Organization Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cytokine Production Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immune Response Immune System Process DNA-templated Transcription, Termination Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transcription, DNA-templated Negative Regulation Of Actin Nucleation Response To Stimulus Regulation Of Apoptotic Process RNA Biosynthetic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Death Glial Cell Development Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Cellular Process Actin Filament Organization Regulation Of Actin Nucleation RNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune System Process
Tagcloud ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn1 splice unusually weakness	add biosynthesis burgeoning codified codifies collins constituent crest disrupts elucidating genetics hemizygous heterozygosity illustrating implicates nascent neuroepithelium pathophysiology planning playing researchers ribosome tcof1 tcs treacher treacle underpinnings utilizing
Tagcloud (Difference) ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn1 splice unusually weakness	add biosynthesis burgeoning codified codifies collins constituent crest disrupts elucidating genetics hemizygous heterozygosity illustrating implicates nascent neuroepithelium pathophysiology planning playing researchers ribosome tcof1 tcs treacher treacle underpinnings utilizing
Tagcloud (Intersection) ?