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SMN2 and DHX9
Number of citations of the paper that reports this interaction (PMID
11149922
)
46
Data Source:
HPRD
(in vivo, in vitro)
SMN2
DHX9
Gene Name
survival of motor neuron 2, centromeric
DEAH (Asp-Glu-Ala-His) box helicase 9
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Cytoplasm
Cytosol
Cajal Body
Z Disc
SMN Complex
SMN-Sm Protein Complex
Gemini Of Coiled Bodies
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Membrane
Ribonucleoprotein Complex
Cytoplasmic Ribonucleoprotein Granule
CRD-mediated MRNA Stability Complex
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
RNA Helicase Activity
ATP-dependent DNA Helicase Activity
ATP-dependent RNA Helicase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Biological Process
Spliceosomal Complex Assembly
Spliceosomal SnRNP Assembly
Nervous System Development
Gene Expression
NcRNA Metabolic Process
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
RNA Processing
Circadian Rhythm
RNA Splicing
Gene Expression
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Cellular Response To Heat
Innate Immune Response
CRD-mediated MRNA Stabilization
Pathways
snRNP Assembly
Metabolism of non-coding RNA
mRNA Splicing
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
Processing of Capped Intron-Containing Pre-mRNA
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
mRNA Splicing - Major Pathway
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions
24 interactors:
BLOC1S6
BYSL
CHTOP
DDX20
DHX9
FAM9B
FBL
GAR1
GEMIN2
HNRNPUL1
POLR1C
POLR2A
PPIG
SMN1
SNRPB
SNRPB2
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
TIAL1
VPS28
40 interactors:
ACTA1
AKAP8L
APBB1
BRCA1
DDX20
DDX5
EIF2AK2
EWSR1
GEMIN2
GEMIN4
GTF2B
H2AFX
HDLBP
HNRNPC
HNRNPK
IL7R
ILF3
JUN
KHDRBS1
MBD2
MGEA5
NXF1
PCNA
POLR2A
PRMT1
PRPF40A
PRPF8
RBM4
RELA
SMN1
SMN2
SNRPB
SNRPB2
SRPK1
SSRP1
STAU1
TBP
TOP2A
UBE2I
YWHAQ
Entrez ID
6607
1660
HPRD ID
09036
04386
Ensembl ID
ENSG00000205571
ENSG00000135829
Uniprot IDs
B4DP61
Q16637
B3KU66
Q08211
PDB IDs
1G5V
1MHN
2LEH
3S6N
4A4E
4A4G
4GLI
3LLM
3VYX
3VYY
Enriched GO Terms of Interacting Partners
?
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Spliceosomal SnRNP Assembly
RNA Splicing
RNA Processing
MRNA Processing
Ribonucleoprotein Complex Biogenesis
NcRNA Metabolic Process
MRNA Metabolic Process
Ribonucleoprotein Complex Assembly
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Histone MRNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
Spliceosomal Complex Assembly
Cellular Nitrogen Compound Metabolic Process
DNA-templated Transcription, Termination
Cellular Macromolecular Complex Assembly
Nitrogen Compound Metabolic Process
Termination Of RNA Polymerase II Transcription
MRNA 3'-end Processing
RNA 3'-end Processing
Cellular Metabolic Process
Cellular Component Assembly
Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
RRNA Processing
RRNA Metabolic Process
Metabolic Process
Ribosome Biogenesis
Histone Glutamine Methylation
Cellular Process
Transcription, RNA-templated
Peptidyl-glutamine Methylation
Positive Regulation Of Type I Interferon Production
Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
DNA-templated Transcription, Elongation
SnoRNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
CRD-mediated MRNA Stabilization
Regulation Of Type I Interferon Production
Endosome Transport Via Multivesicular Body Sorting Pathway
Positive Regulation Of Helicase Activity
Secretion Of Lysosomal Enzymes
Late Endosome To Vacuole Transport
Osteoblast Differentiation
MRNA Processing
RNA Splicing
MRNA Metabolic Process
RNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Spliceosomal SnRNP Assembly
Nitrogen Compound Metabolic Process
Regulation Of Viral Process
Regulation Of Viral Genome Replication
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Viral Process
Positive Regulation Of DNA Metabolic Process
Regulation Of Gene Expression
Ribonucleoprotein Complex Assembly
Viral Process
Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Cellular Macromolecular Complex Assembly
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Ribonucleoprotein Complex Biogenesis
Negative Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Chromosome Organization
Positive Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Viral Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Viral Genome Replication
Tagcloud
?
atrophy
centromeric
compensate
copies
copy
degeneration
deletions
detectable
display
donor
easily
exon
fails
fatal
harbor
hindering
homozygous
infant
intragenic
italian
modifier
muscular
null
predictable
sma
smn1
splice
unusually
weakness
Tagcloud (Difference)
?
atrophy
centromeric
compensate
copies
copy
degeneration
deletions
detectable
display
donor
easily
exon
fails
fatal
harbor
hindering
homozygous
infant
intragenic
italian
modifier
muscular
null
predictable
sma
smn1
splice
unusually
weakness
Tagcloud (Intersection)
?