SMN2 and CHTOP

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SMN2	CHTOP
Name		survival of motor neuron 2, centromeric	chromatin target of PRMT1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies	Transcription Export Complex Nucleus Nucleoplasm Nucleolus Nuclear Speck
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	RNA Binding Protein Binding Methyl-CpG Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing	In Utero Embryonic Development Chromatin Remodeling MRNA Export From Nucleus Positive Regulation Of ATP-dependent Activity MRNA Transport Positive Regulation Of Helicase Activity
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Nusinersen	None
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		37 interacting genes: BLOC1S6 BYSL CHTOP DDX20 DHX9 EHHADH FAM9B FBL FNDC11 GAR1 GEMIN2 HNRNPUL1 IQUB KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 MAGED1 MBD2 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNU13 SPANXN2 TIAL1 USP9X VPS28	11 interacting genes: APOBEC3C APP CEBPA GSK3A KHDRBS2 PHLDB3 RBM3 SMN1 SMN2 SNRPA SRPK2
Entrez ID		6607	26097
HPRD ID		09036	13163
Ensembl ID		ENSG00000205571	ENSG00000160679
Uniprot IDs		B4DP61 E7EQZ4 Q16637	A0A087X1B7 Q9Y3Y2
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30	Not available
GO Terms Enriched among Interactors		SMN-Sm Protein Complex Spliceosomal SnRNP Assembly 7-methylguanosine Cap Hypermethylation Spliceosomal Complex Assembly U1 SnRNP U4 SnRNP Methylosome Protein-RNA Complex Assembly U2-type Prespliceosome Assembly RNA Splicing, Via Transesterification Reactions RNA Splicing U2 SnRNP U2-type Precatalytic Spliceosome U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Small Nuclear Ribonucleoprotein Complex U5 SnRNP U4/U6 X U5 Tri-snRNP Complex RNA Processing U12-type Spliceosomal Complex MRNA Processing PICln-Sm Protein Complex MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex MRNA Metabolic Process U7 SnRNP Precatalytic Spliceosome Spliceosomal Complex RNA Methylation RNA Metabolic Process Catalytic Step 2 Spliceosome RNA Binding RNA Modification Macromolecule Methylation Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Methylation Nucleoplasm Telomerase Holoenzyme Complex Protein-containing Complex Assembly Spliceosomal Tri-snRNP Complex Cellular Component Assembly Protein-containing Complex Organization Cytosol SMN Complex Gemini Of Cajal Bodies DNA-templated Transcription Termination Telomerase RNA Binding Intermediate Filament Histone Pre-mRNA DCP Binding	RNA Binding Spliceosomal Complex Assembly Positive Regulation Of Neuron Apoptotic Process RNA Metabolic Process RNA Processing MRNA Processing SMN Complex Gemini Of Cajal Bodies MRNA Metabolic Process Response To Lithium Ion Cellular Response To Lithium Ion Regulation Of MRNA Splicing, Via Spliceosome SMN-Sm Protein Complex Positive Regulation Of Gene Expression DNA-templated Transcription Termination RNA Splicing Regulation Of MRNA Processing Axon Perikaryon Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Nucleic Acid Metabolic Process Cellular Response To Metal Ion Regulation Of RNA Splicing Protein-RNA Complex Assembly Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process RNA Splicing, Via Transesterification Reactions Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Spliceosomal SnRNP Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of UDP-glucose Catabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Cajal Body Regulation Of Carbohydrate Catabolic Process Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity Response To Metal Ion Lipoprotein Particle