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SMN2 and TIAL1
Number of citations of the paper that reports this interaction (PubMedID
15304326
)
0
Data Source:
HPRD
(in vivo)
SMN2
TIAL1
Description
survival of motor neuron 2, centromeric
TIA1 cytotoxic granule associated RNA binding protein like 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Perikaryon
Gemini Of Cajal Bodies
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Stress Granule
Cytolytic Granule
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
Nucleic Acid Binding
DNA Binding
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Protein-RNA Adaptor Activity
Biological Process
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
Spliceosomal SnRNP Assembly
DNA-templated Transcription Termination
MRNA Processing
Nervous System Development
RNA Splicing
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Defense Response
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Hippo Signaling
Regulation Of Cell Population Proliferation
Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways
snRNP Assembly
SARS-CoV-2 modulates host translation machinery
FGFR2 alternative splicing
Drugs
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Depressive symptoms (stressful life events interaction) (
27529621
)
Monocyte percentage of white cells (
32888494
)
Parkinson's disease (
27182965
)
Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) (
27047539
)
Interacting Genes
37 interacting genes:
BLOC1S6
BYSL
CHTOP
DDX20
DHX9
EHHADH
FAM9B
FBL
FNDC11
GAR1
GEMIN2
HNRNPUL1
IQUB
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
MAGED1
MBD2
POLR1C
POLR2A
PPIG
SMN1
SNRPB
SNRPB2
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
SNU13
SPANXN2
TIAL1
USP9X
VPS28
42 interacting genes:
AKAP8L
AOC1
BPIFA1
C10orf55
CAMK2A
CEBPA
CELF4
CREBBP
DAZAP2
FAM168A
FAM168B
FUBP1
GRINA
INCA1
KLF1
KRT31
KRTAP8-1
MAGED1
MAPK1
MAPK1IP1L
MBNL2
MIR106A
MIR106B
MIR145
MIR199A1
MIR20A
MIR29A
MIR29C
MIR34A
MIR9-2
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QKI
RBPMS2
SMN1
SMN2
SNRPA
VPS37C
Entrez ID
6607
7073
HPRD ID
09036
04563
Ensembl ID
ENSG00000205571
ENSG00000151923
Uniprot IDs
B4DP61
E7EQZ4
Q16637
Q01085
Q49AS9
PDB IDs
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
7W2P
7W30
1X4G
2CQI
2DH7
Enriched GO Terms of Interacting Partners
?
SMN-Sm Protein Complex
Spliceosomal SnRNP Assembly
7-methylguanosine Cap Hypermethylation
Spliceosomal Complex Assembly
U1 SnRNP
U4 SnRNP
Methylosome
Protein-RNA Complex Assembly
U2-type Prespliceosome Assembly
RNA Splicing, Via Transesterification Reactions
RNA Splicing
U2 SnRNP
U2-type Precatalytic Spliceosome
U2-type Spliceosomal Complex
U2-type Catalytic Step 2 Spliceosome
Small Nuclear Ribonucleoprotein Complex
U5 SnRNP
U4/U6 X U5 Tri-snRNP Complex
RNA Processing
U12-type Spliceosomal Complex
MRNA Processing
PICln-Sm Protein Complex
MRNA Splicing, Via Spliceosome
Ribonucleoprotein Complex
MRNA Metabolic Process
U7 SnRNP
Precatalytic Spliceosome
Spliceosomal Complex
RNA Methylation
RNA Metabolic Process
Catalytic Step 2 Spliceosome
RNA Binding
RNA Modification
Macromolecule Methylation
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Methylation
Nucleoplasm
Telomerase Holoenzyme Complex
Protein-containing Complex Assembly
Spliceosomal Tri-snRNP Complex
Cellular Component Assembly
Protein-containing Complex Organization
Cytosol
SMN Complex
Gemini Of Cajal Bodies
DNA-templated Transcription Termination
Telomerase RNA Binding
Intermediate Filament
Histone Pre-mRNA DCP Binding
MRNA Base-pairing Post-transcriptional Repressor Activity
MiRNA-mediated Post-transcriptional Gene Silencing
MRNA 3'-UTR Binding
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Gene Silencing
Regulation Of Cardiac Muscle Cell Apoptotic Process
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Translation
Negative Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Vasculature Development
Negative Regulation Of Angiogenesis
Extracellular Vesicle
Post-transcriptional Regulation Of Gene Expression
Regulation Of Angiogenesis
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Vasculature Development
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Developmental Process
Negative Regulation Of Striated Muscle Cell Apoptotic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Translation
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Muscle Cell Apoptotic Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of MRNA Metabolic Process
Negative Regulation Of Cytokine Production
Positive Regulation Of Tissue Remodeling
Negative Regulation Of Circulating Fibrinogen Levels
Negative Regulation Of BMP Signaling Pathway
RNA Splicing
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Gene Expression
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
MRNA Processing
Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
MRNA Destabilization
Regulation Of MRNA Stability
RNA Destabilization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Migration
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