NADK and GLRX3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NADK	GLRX3
Gene Name		NAD kinase	glutaredoxin 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cell Cortex Z Disc Extracellular Vesicular Exosome
	Molecular Function	NAD+ Kinase Activity ATP Binding Metal Ion Binding	Protein Kinase C Binding Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Poly(A) RNA Binding Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	NADP Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Phosphorylation NAD Metabolic Process Small Molecule Metabolic Process ATP Metabolic Process	Regulation Of The Force Of Heart Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Cell Redox Homeostasis Oxidation-reduction Process
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS			HIV-1 susceptibility ( 21160409)
Protein-Protein Interactions		7 interactors: EEF1G GLRX3 GRB2 LNX1 NUDT18 SDCBP YWHAQ	57 interactors: ADAMTSL4 ALKBH3 BOLA1 CBLB CGGBP1 CIAPIN1 EFEMP2 FAM118A FRA10AC1 GMCL1 GRN HEXDC IKZF1 KRT31 KRT38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE2D MAP3K3 MAPK6 MAPKBP1 MOXD1 NADK NOTCH2NL OLFM3 PCSK5 PFDN5 PLSCR1 PRKCQ PRKCZ PRKD2 RGS20 SOX7 STAU1 TCF4 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF148 ZNF426 ZNF512B ZNF544
Entrez ID		65220	10539
HPRD ID		16907	10153
Ensembl ID		ENSG00000008130	ENSG00000108010
Uniprot IDs		O95544 Q6PJ22	O76003
PDB IDs		3PFN	2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Small GTPase Mediated Signal Transduction Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Ras Protein Signal Transduction Regulation Of Organelle Organization Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Deoxyribonucleoside Diphosphate Metabolic Process Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Cellular Component Biogenesis Substrate-dependent Cell Migration, Cell Extension Purine Ribonucleoside Catabolic Process Positive Regulation Of Signal Transduction Deoxyribose Phosphate Catabolic Process Axon Guidance Protein Targeting Protein Oligomerization Labyrinthine Layer Morphogenesis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Developmental Process Positive Regulation Of Interleukin-4 Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Interleukin-4 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Cell Activation Regulation Of T Cell Activation Cell Death Death Multicellular Organismal Development Positive Regulation Of Interleukin-2 Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Anatomical Structure Development Positive Regulation Of Neutrophil Differentiation Renin Secretion Into Blood Stream Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cellular Process Transcription, DNA-templated Regulation Of T Cell Receptor Signaling Pathway Embryonic Digestive Tract Development Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction RNA Biosynthetic Process Regulation Of Lymphocyte Activation Protein Kinase D Signaling Positive Regulation Of T-helper 2 Cell Activation Oxidative Single-stranded DNA Demethylation Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Positive Regulation Of T Cell Activation
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?