SLC2A4 and AP1M1

Number of citations of the paper that reports this interaction (PubMedID 19558319)
0

Data Source:
BioGRID (pull down)

		SLC2A4	AP1M1
Description		solute carrier family 2 member 4	adaptor related protein complex 1 subunit mu 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Vesicle Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome
	Molecular Function	Protein Binding D-glucose Uniporter Activity Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	Protein Binding Clathrin Adaptor Activity
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol D-glucose Import Brown Fat Cell Differentiation Transmembrane Transport White Fat Cell Proliferation Dehydroascorbic Acid Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier D-glucose Transmembrane Transport	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Two-hour glucose ( 34059833)	Coronary artery disease ( 33020668)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16
Entrez ID		6517	8907
HPRD ID		00688	04639
Ensembl ID		ENSG00000181856	ENSG00000072958
Uniprot IDs		P14672	B3KNH5 Q59EK3 Q9BXS5
PDB IDs		7WSM 7WSN
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Perinuclear Region Of Cytoplasm Regulation Of Establishment Of Protein Localization Pseudopodium Catabolic Process Collagen Fibril Organization Regulation Of Protein Localization Regulation Of Protein Secretion Regulation Of Transport Cytosol Response To Unfolded Protein Regulation Of Protein Transport Melanosome Cellular Localization Actin Cytoskeleton Organization Cytoplasm Ficolin-1-rich Granule Lumen Oxidoreductase Activity Cortical Actin Cytoskeleton Intracellular Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Secretion By Cell Organelle Organization Actin Filament-based Process Collagen Biosynthetic Process Positive Regulation Of Transport Intracellular Protein Localization Establishment Of Protein Localization Protein Metabolic Process Regulation Of Secretion Collagen Metabolic Process Collagen Binding Macromolecule Catabolic Process Protein Catabolic Process Pyruvate Metabolic Process Protein Hydroxylation Monocarboxylic Acid Metabolic Process Protein Transport Response To Peptide Hormone Ubiquitin Protein Ligase Binding 2-oxoglutarate Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Derivative Metabolic Process Protein Localization To Plasma Membrane Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Actin Filament Binding Very Long-chain Fatty Acid Beta-oxidation Cytoskeleton Organization Positive Regulation Of Cell Motility	Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process
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