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SLC2A4 and UBE2N
Number of citations of the paper that reports this interaction (PubMedID
16396496
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
SLC2A4
UBE2N
Description
solute carrier family 2 member 4
ubiquitin conjugating enzyme E2 N
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Multivesicular Body
Trans-Golgi Network
Cytosol
Plasma Membrane
Clathrin-coated Pit
External Side Of Plasma Membrane
Cell Surface
Endomembrane System
Vesicle Membrane
Membrane
Sarcoplasmic Reticulum
Clathrin-coated Vesicle
Trans-Golgi Network Transport Vesicle
T-tubule
Cytoplasmic Vesicle Membrane
Vesicle
Insulin-responsive Compartment
Sarcolemma
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Presynapse
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ubiquitin Conjugating Enzyme Complex
UBC13-MMS2 Complex
Protein-containing Complex
Extracellular Exosome
Molecular Function
Protein Binding
D-glucose Uniporter Activity
Transmembrane Transporter Activity
D-glucose Transmembrane Transporter Activity
Nucleotide Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activator Activity
Biological Process
Carbohydrate Metabolic Process
Learning Or Memory
Short-term Memory
Long-term Memory
Amylopectin Biosynthetic Process
Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Glucose Homeostasis
Glucose Import In Response To Insulin Stimulus
Response To Ethanol
D-glucose Import
Brown Fat Cell Differentiation
Transmembrane Transport
White Fat Cell Proliferation
Dehydroascorbic Acid Transport
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Osmotic Stress
Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Transport Across Blood-brain Barrier
D-glucose Transmembrane Transport
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein K63-linked Ubiquitination
Antiviral Innate Immune Response
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Double-strand Break Repair
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Cellular hexose transport
Transcriptional regulation of white adipocyte differentiation
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PINK1-PRKN Mediated Mitophagy
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
34315874
33547301
)
Apolipoprotein B levels (
32203549
)
Aspartate aminotransferase levels (
34315874
33547301
)
Birth weight (
23202124
31043758
)
Diastolic blood pressure (
28135244
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Medication use (diuretics) (
31015401
)
Metabolite levels (
22286219
)
Offspring birth weight (
31043758
)
Pulse pressure (
28135244
)
Systolic blood pressure (
30578418
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Two-hour glucose (
34059833
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
40 interacting genes:
ACOX1
ACTN1
ACTN4
AKT2
AP1M1
ARF3
ARFIP1
BSG
C1QTNF5
CCDC116
CFL1
CREB3
CTSD
DAXX
DLD
EHD2
ESYT2
FAR1
FKBP10
GAPDH
HADH
HK2
HSP90AA1
IDH2
KLHL41
LNPEP
MAP1S
MVP
P3H1
P3H4
PDIA6
PRKAR1A
PSMD7
RAB7A
SERPINH1
SRFBP1
STRN3
UBA52
UBE2I
UBE2N
124 interacting genes:
AMFR
ARIH1
ARIH2
ARK2C
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DTX3
DZIP3
F12
H2AC4
HERC2
HSP90AA1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RBX1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF167
RNF168
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TREX2
TRIM13
TRIM14
TRIM15
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM34
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM65
TRIM69
TRIM7
TRIM72
UBA1
UBB
UBE2V1
UBE2V2
UBE3A
UBE3B
UHRF1
XIAP
ZNRF2
ZNRF3
ZNRF4
Entrez ID
6517
7334
HPRD ID
00688
04725
Ensembl ID
ENSG00000181856
ENSG00000177889
Uniprot IDs
P14672
P61088
V9HW41
PDB IDs
7WSM
7WSN
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6LP2
6P5B
6S53
6ULH
6UMP
6UMS
7BBD
7BBF
7BXG
9BIV
Enriched GO Terms of Interacting Partners
?
Extracellular Exosome
Perinuclear Region Of Cytoplasm
Regulation Of Establishment Of Protein Localization
Pseudopodium
Catabolic Process
Collagen Fibril Organization
Regulation Of Protein Localization
Regulation Of Protein Secretion
Regulation Of Transport
Cytosol
Response To Unfolded Protein
Regulation Of Protein Transport
Melanosome
Cellular Localization
Actin Cytoskeleton Organization
Cytoplasm
Ficolin-1-rich Granule Lumen
Oxidoreductase Activity
Cortical Actin Cytoskeleton
Intracellular Transport
Regulation Of Matrix Metallopeptidase Secretion
Regulation Of Secretion By Cell
Organelle Organization
Actin Filament-based Process
Collagen Biosynthetic Process
Positive Regulation Of Transport
Intracellular Protein Localization
Establishment Of Protein Localization
Protein Metabolic Process
Regulation Of Secretion
Collagen Metabolic Process
Collagen Binding
Macromolecule Catabolic Process
Protein Catabolic Process
Pyruvate Metabolic Process
Protein Hydroxylation
Monocarboxylic Acid Metabolic Process
Protein Transport
Response To Peptide Hormone
Ubiquitin Protein Ligase Binding
2-oxoglutarate Metabolic Process
Generation Of Precursor Metabolites And Energy
Fatty Acid Derivative Metabolic Process
Protein Localization To Plasma Membrane
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor
Protein Homodimerization Activity
Actin Filament Binding
Very Long-chain Fatty Acid Beta-oxidation
Cytoskeleton Organization
Positive Regulation Of Cell Motility
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Transferase Activity
Protein Polyubiquitination
Zinc Ion Binding
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Macromolecule Catabolic Process
Metal Ion Binding
Protein K63-linked Ubiquitination
Protein Autoubiquitination
Proteolysis
Catabolic Process
Protein K48-linked Ubiquitination
Response To Stress
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stress
Regulation Of Intracellular Signal Transduction
Innate Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Protein Monoubiquitination
Immune System Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Defense Response To Symbiont
Cytoplasm
Defense Response To Other Organism
Positive Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
Response To Other Organism
Ubiquitin Conjugating Enzyme Binding
Positive Regulation Of Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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