SLC2A4 and FAR1

Number of citations of the paper that reports this interaction (PubMedID 16396496)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SLC2A4	FAR1
Description		solute carrier family 2 member 4	fatty acyl-CoA reductase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Vesicle Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Peroxisome Peroxisomal Membrane Membrane
	Molecular Function	Protein Binding D-glucose Uniporter Activity Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Alcohol-forming Very Long-chain Fatty Acyl-CoA Reductase Activity Alcohol-forming Long-chain Fatty Acyl-CoA Reductase Activity
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol D-glucose Import Brown Fat Cell Differentiation Transmembrane Transport White Fat Cell Proliferation Dehydroascorbic Acid Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier D-glucose Transmembrane Transport	Lipid Metabolic Process Lipid Biosynthetic Process Ether Lipid Biosynthetic Process Wax Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process Glycerophospholipid Biosynthetic Process Fatty Acid Derivative Metabolic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation	Wax biosynthesis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Two-hour glucose ( 34059833)	Childhood ear infection ( 27182965) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Night sleep phenotypes ( 27126917) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia x sex interaction ( 34099189) Visceral adipose tissue adjusted for BMI ( 26480920)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	2 interacting genes: ATXN1 SLC2A4
Entrez ID		6517	84188
HPRD ID		00688	14724
Ensembl ID		ENSG00000181856	ENSG00000197601
Uniprot IDs		P14672	Q8WVX9
PDB IDs		7WSM 7WSN
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Perinuclear Region Of Cytoplasm Regulation Of Establishment Of Protein Localization Pseudopodium Catabolic Process Collagen Fibril Organization Regulation Of Protein Localization Regulation Of Protein Secretion Regulation Of Transport Cytosol Response To Unfolded Protein Regulation Of Protein Transport Melanosome Cellular Localization Actin Cytoskeleton Organization Cytoplasm Ficolin-1-rich Granule Lumen Oxidoreductase Activity Cortical Actin Cytoskeleton Intracellular Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Secretion By Cell Organelle Organization Actin Filament-based Process Collagen Biosynthetic Process Positive Regulation Of Transport Intracellular Protein Localization Establishment Of Protein Localization Protein Metabolic Process Regulation Of Secretion Collagen Metabolic Process Collagen Binding Macromolecule Catabolic Process Protein Catabolic Process Pyruvate Metabolic Process Protein Hydroxylation Monocarboxylic Acid Metabolic Process Protein Transport Response To Peptide Hormone Ubiquitin Protein Ligase Binding 2-oxoglutarate Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Derivative Metabolic Process Protein Localization To Plasma Membrane Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Actin Filament Binding Very Long-chain Fatty Acid Beta-oxidation Cytoskeleton Organization Positive Regulation Of Cell Motility	Memory Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Learning Or Memory Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cognition POZ Domain Binding White Fat Cell Proliferation Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus Poly(G) Binding Dehydroascorbic Acid Transport Fat Cell Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway D-glucose Transmembrane Transporter Activity Nuclear Inclusion Body Short-term Memory Trans-Golgi Network Transport Vesicle D-glucose Import Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Nervous System Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Brown Fat Cell Differentiation D-glucose Transmembrane Transport Insulin-like Growth Factor Receptor Signaling Pathway Long-term Memory Hexose Transmembrane Transport Vesicle Membrane Regulation Of Glial Cell Proliferation Lung Alveolus Development Cellular Response To Osmotic Stress Carbohydrate Transport Vitamin Transport Carbohydrate Transmembrane Transport T-tubule Multivesicular Body Visual Learning Social Behavior Visual Behavior Excitatory Postsynaptic Potential Macromolecule Biosynthetic Process System Process Positive Regulation Of Gliogenesis Sarcoplasmic Reticulum Clathrin-coated Pit Response To Osmotic Stress Adult Locomotory Behavior Clathrin-coated Vesicle
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