SLC2A4 and P3H4

Number of citations of the paper that reports this interaction (PubMedID 16396496)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SLC2A4	P3H4
Description		solute carrier family 2 member 4	prolyl 3-hydroxylase family member 4 (inactive)
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Vesicle Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Condensed Nuclear Chromosome Synaptonemal Complex Nucleolus Endoplasmic Reticulum Catalytic Complex
	Molecular Function	Protein Binding D-glucose Uniporter Activity Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	Collagen Binding
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol D-glucose Import Brown Fat Cell Differentiation Transmembrane Transport White Fat Cell Proliferation Dehydroascorbic Acid Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier D-glucose Transmembrane Transport	Synaptonemal Complex Assembly Peptidyl-lysine Hydroxylation Collagen Fibril Organization Collagen Biosynthetic Process Bone Remodeling
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Two-hour glucose ( 34059833)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	2 interacting genes: OGT SLC2A4
Entrez ID		6517	10609
HPRD ID		00688	10126
Ensembl ID		ENSG00000181856	ENSG00000141696
Uniprot IDs		P14672	Q92791
PDB IDs		7WSM 7WSN
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Perinuclear Region Of Cytoplasm Regulation Of Establishment Of Protein Localization Pseudopodium Catabolic Process Collagen Fibril Organization Regulation Of Protein Localization Regulation Of Protein Secretion Regulation Of Transport Cytosol Response To Unfolded Protein Regulation Of Protein Transport Melanosome Cellular Localization Actin Cytoskeleton Organization Cytoplasm Ficolin-1-rich Granule Lumen Oxidoreductase Activity Cortical Actin Cytoskeleton Intracellular Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Secretion By Cell Organelle Organization Actin Filament-based Process Collagen Biosynthetic Process Positive Regulation Of Transport Intracellular Protein Localization Establishment Of Protein Localization Protein Metabolic Process Regulation Of Secretion Collagen Metabolic Process Collagen Binding Macromolecule Catabolic Process Protein Catabolic Process Pyruvate Metabolic Process Protein Hydroxylation Monocarboxylic Acid Metabolic Process Protein Transport Response To Peptide Hormone Ubiquitin Protein Ligase Binding 2-oxoglutarate Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Derivative Metabolic Process Protein Localization To Plasma Membrane Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Actin Filament Binding Very Long-chain Fatty Acid Beta-oxidation Cytoskeleton Organization Positive Regulation Of Cell Motility	Carbohydrate Homeostasis Amylopectin Biosynthetic Process Glucose Homeostasis D-glucose Uniporter Activity Response To Insulin Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Response To Peptide Hormone Protein O-acetylglucosaminyltransferase Activity Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus White Fat Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbohydrate Derivative Biosynthetic Process Carbon Catabolite Regulation Of Transcription Dehydroascorbic Acid Transport Fat Cell Proliferation Regulation Of Transcription By Glucose D-glucose Transmembrane Transporter Activity Response To Hormone NSL Complex Short-term Memory Trans-Golgi Network Transport Vesicle D-glucose Import Carbohydrate Derivative Metabolic Process Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cellular Response To Oxygen-containing Compound Chemical Homeostasis Sin3-type Complex Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Synapse Brown Fat Cell Differentiation D-glucose Transmembrane Transport Regulation Of Receptor Localization To Synapse Regulation Of Necroptotic Process Hexose Transmembrane Transport Regulation Of Rac Protein Signal Transduction Long-term Memory Vesicle Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Cellular Response To Nutrient Regulation Of Programmed Necrotic Cell Death Cellular Response To Osmotic Stress
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