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MARCH7 and VAV2
Number of citations of the paper that reports this interaction (PMID
18654987
)
7
Data Source:
BioGRID
(two hybrid)
MARCH7
VAV2
Gene Name
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
vav 2 guanine nucleotide exchange factor
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Molecular Function
Zinc Ion Binding
Ligase Activity
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
Metal Ion Binding
Biological Process
Protein Ubiquitination
Angiogenesis
Signal Transduction
Small GTPase Mediated Signal Transduction
Axon Guidance
Blood Coagulation
Regulation Of Gene Expression
Cell Migration
Lamellipodium Assembly
Platelet Activation
Regulation Of Blood Coagulation
Positive Regulation Of Rho GTPase Activity
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Signaling by GPCR
Axon guidance
L1CAM interactions
FCERI mediated MAPK activation
VEGFA-VEGFR2 Pathway
Rho GTPase cycle
DAP12 signaling
EPH-ephrin mediated repulsion of cells
VEGFR2 mediated vascular permeability
EPH-Ephrin signaling
G alpha (12/13) signalling events
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Signalling by NGF
DAP12 interactions
Signal transduction by L1
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
GPCR downstream signaling
Signaling by VEGF
NRAGE signals death through JNK
Signaling by Rho GTPases
GPVI-mediated activation cascade
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Multiple sclerosis (
20598377
)
vWF and FVIII levels (
21810271
)
Protein-Protein Interactions
15 interactors:
MAPT
PPP3CA
PPP3CB
RNF111
TRIM65
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2K
UBE2M
UBE2N
USP7
VAV2
62 interactors:
ARIH1
BIRC6
BOD1L1
BRDT
BZW1
CBL
CBLB
CCNO
CCT2
CCT3
CD19
CD44
CEP170
CHMP3
CRCP
DCUN1D4
DNAJC21
EGFR
EIF4G3
EPHB2
ERBB2
ERBB3
FNTA
FUCA1
FYN
GAPVD1
GRB2
HNRNPF
HSPH1
IPO4
MARCH7
MED21
MRGBP
NCKAP5
NEK3
PHF10
PNMA1
POGZ
PPM1B
PRLR
RAC1
RAD23A
RBBP6
RHOA
RHOG
SERBP1
SF3A3
SH3BP2
SNW1
SOCS1
SRPK2
SRRT
ST13
STK24
SYK
TARBP2
TCP11
TOM1L1
TTN
UBE4B
USP38
VCPIP1
Entrez ID
64844
7410
HPRD ID
09817
02694
Ensembl ID
ENSG00000160293
Uniprot IDs
Q9H992
P52735
PDB IDs
2DLZ
2DM1
2LNW
2LNX
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K48-linked Ubiquitination
Immune Response-regulating Signaling Pathway
Cellular Macromolecule Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Protein Modification Process
Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Regulation Of Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Activation Of Innate Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Proteolysis
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Cellular Response To Transforming Growth Factor Beta Stimulus
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Response To Transforming Growth Factor Beta
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination
Cellular Protein Metabolic Process
Positive Regulation Of Ligase Activity
Catabolic Process
Response To Organic Substance
Fc-epsilon Receptor Signaling Pathway
Cellular Response To Organic Substance
Immune Response
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Immune System Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Innate Immune Response
Defense Response
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Fc Receptor Signaling Pathway
Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Response To Fibroblast Growth Factor
Phosphatidylinositol-mediated Signaling
Cellular Response To Organic Substance
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Response To Organic Substance
Peptidyl-tyrosine Phosphorylation
Fc Receptor Signaling Pathway
Platelet Activation
Innate Immune Response
Regulation Of Cellular Protein Metabolic Process
Cellular Protein Modification Process
Cellular Metabolic Process
Protein Metabolic Process
Positive Regulation Of Viral Process
Regulation Of Body Fluid Levels
Wound Healing
Immune Response
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Axon Guidance
Cell Activation
Regulation Of Signal Transduction
Response To Wounding
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of T Cell Activation
Viral Process
Positive Regulation Of Signal Transduction
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Hemostasis
Protein Ubiquitination
Regulation Of Immune System Process
Signal Transduction
Regulation Of Intracellular Signal Transduction
Chemotaxis
Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
wilcoxon
yes
zfyve9
Tagcloud (Difference)
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
wilcoxon
yes
zfyve9
Tagcloud (Intersection)
?