MARCHF7 and TRIM65

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		MARCHF7	TRIM65
Description		membrane associated ring-CH-type finger 7	tripartite motif containing 65
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Tolerance Induction Protein Monoubiquitination Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of T Cell Proliferation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Protein Autoubiquitination Cilium Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Protein Autoubiquitination	Immune System Process Inflammatory Response Positive Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Protein Oligomerization Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Inflammatory Response Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 30002152 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		22 interacting genes: ATG14 CTNNA3 EXOC8 HSF2BP IQCB1 MAPRE1 MAPRE3 MAPT NLRP3 PPP3CA PPP3CB RNF111 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2K UBE2M UBE2N USP7	15 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 RIGI SRPK1 TNRC6A TP53 UBE2D2 UBE2N UBE2U UBE2Z UBE3A VCAM1
Entrez ID		64844	201292
HPRD ID		09817	15569
Ensembl ID		ENSG00000136536	ENSG00000141569
Uniprot IDs		B7Z5K0 B7ZAR7 F5H6W4 Q9H992	Q6PJ69
PDB IDs			7JL0 7JL2 7JL4
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Cytosol Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Mitotic Spindle Astral Microtubule End Calmodulin-dependent Protein Phosphatase Activity Macromolecule Metabolic Process Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Protein Monoubiquitination Catabolic Process Protein Serine/threonine Phosphatase Complex Positive Regulation Of Metabolic Process Positive Regulation Of Calcium Ion Import Across Plasma Membrane Ubiquitin Protein Ligase Activity TORC1 Signaling Regulation Of Microtubule Polymerization Negative Regulation Of TORC1 Signaling Regulation Of Autophagy Positive Regulation Of Protein Modification Process Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Protein-containing Complex Assembly Protein Polymerization Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Localization To Microtubule Transferase Activity TOR Signaling Regulation Of Protein-containing Complex Assembly ATP Binding Organelle Assembly Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Polyubiquitination Microtubule Organizing Center Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of TORC1 Signaling Regulation Of Microtubule Polymerization Or Depolymerization	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Transferase Activity Macromolecule Metabolic Process Detection Of Virus Regulation Of Type III Interferon Production Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process MRNA Transcription Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Antiviral Innate Immune Response Response To Nutrient Levels MDM2/MDM4 Family Protein Binding Cellular Response To Nutrient Levels Catabolic Process Zinc Ion Binding ATP Binding Cellular Response To Exogenous DsRNA Ubiquitin Binding Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Polyubiquitination Protein Catabolic Process Cytosol Cellular Response To DsRNA Positive Regulation Of Post-translational Protein Modification Immune Response-activating Signaling Pathway Positive Regulation Of Interferon-alpha Production Regulation Of Protein Polyubiquitination Nucleotide Binding Immune Response-regulating Signaling Pathway Response To Stress Activation Of Immune Response Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Programmed Necrotic Cell Death Response To External Biotic Stimulus Immune System Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
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