MARCHF7

Description		membrane associated ring-CH-type finger 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Regulation Of Tolerance Induction Protein Monoubiquitination Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of T Cell Proliferation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Protein Autoubiquitination Cilium Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		22 interacting genes: ATG14 CTNNA3 EXOC8 HSF2BP IQCB1 MAPRE1 MAPRE3 MAPT NLRP3 PPP3CA PPP3CB RNF111 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2K UBE2M UBE2N USP7
Entrez ID		64844
HPRD ID		09817
Ensembl ID		ENSG00000136536
Uniprot IDs		B7Z5K0 B7ZAR7 F5H6W4 Q9H992
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Cytosol Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Mitotic Spindle Astral Microtubule End Calmodulin-dependent Protein Phosphatase Activity Macromolecule Metabolic Process Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Protein Monoubiquitination Catabolic Process Protein Serine/threonine Phosphatase Complex Positive Regulation Of Metabolic Process Positive Regulation Of Calcium Ion Import Across Plasma Membrane Ubiquitin Protein Ligase Activity TORC1 Signaling Regulation Of Microtubule Polymerization Negative Regulation Of TORC1 Signaling Regulation Of Autophagy Positive Regulation Of Protein Modification Process Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Protein-containing Complex Assembly Protein Polymerization Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Localization To Microtubule Transferase Activity TOR Signaling Regulation Of Protein-containing Complex Assembly ATP Binding Organelle Assembly Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Polyubiquitination Microtubule Organizing Center Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of TORC1 Signaling Regulation Of Microtubule Polymerization Or Depolymerization
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