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MARCH7 and MAPT
Number of citations of the paper that reports this interaction (PMID
24905733
)
0
Data Source:
BioGRID
(enzymatic study)
MARCH7
MAPT
Gene Name
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
microtubule-associated protein tau
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Microtubule
Microtubule Associated Complex
Plasma Membrane
Axoneme
Axon
Growth Cone
Nuclear Periphery
Cytoplasmic Ribonucleoprotein Granule
Tubulin Complex
Molecular Function
Zinc Ion Binding
Ligase Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Microtubule Binding
SH3 Domain Binding
Enzyme Binding
Protein Kinase Binding
Apolipoprotein Binding
Lipoprotein Particle Binding
Biological Process
Protein Ubiquitination
Microtubule Cytoskeleton Organization
Neuron Migration
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Adult Walking Behavior
Axon Cargo Transport
Regulation Of Autophagy
Regulation Of Microtubule Polymerization
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Intracellular Transport
Positive Regulation Of Axon Extension
Mitochondrion Transport Along Microtubule
Axon Extension
Generation Of Neurons
Regulation Of Microtubule-based Movement
Pathways
Apoptotic cleavage of cellular proteins
Programmed Cell Death
Apoptotic execution phase
Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS
Bone mineral density (
22504420
)
Head circumference (infant) (
22504419
)
Interstitial lung disease (
23583980
)
Intracranial volume (
22504418
)
Parkinson's disease (
20711177
21292315
19915575
22438815
20070850
21044948
21738487
)
Progressive supranuclear palsy (
21685912
)
Protein-Protein Interactions
15 interactors:
MAPT
PPP3CA
PPP3CB
RNF111
TRIM65
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2K
UBE2M
UBE2N
USP7
VAV2
78 interactors:
AATF
ABL1
ACTB
AKT1
APOE
APP
ARHGEF40
BAG1
CALM1
CAMK2A
CAPN2
CASP1
CASP3
CASP6
CASP7
CASP8
CDK1
CDK2
CDK5
CDK5R1
CSNK1A1
CSNK1D
CSNK2A1
EP300
FYN
GSK3A
GSK3B
HSPA4
HSPA8
LRRK2
MAPK11
MAPK12
MAPK13
MAPK8
MARCH7
MARK1
MARK2
MARK3
MARK4
OGT
PEG10
PHKG1
PIN1
PKN1
PPP2CA
PPP2CB
PPP2R4
PPP2R5A
PPP5C
PRKACA
PRKAR1A
PRKCD
PSEN1
PTK2B
RPS6KA1
RPS6KA3
RPS6KA5
RPS6KB1
S100B
SGK1
SIRT1
SNCA
SPTB
SRC
STAU1
STUB1
STXBP1
SYK
TRAF6
TUBA1B
TUBA4A
TUBB
UBB
UBC
UBE2D2
USP9Y
YWHAB
YWHAZ
Entrez ID
64844
4137
HPRD ID
09817
01142
Ensembl ID
ENSG00000186868
Uniprot IDs
Q9H992
B3KTM0
P10636
PDB IDs
1I8H
3FQP
3OVL
4GLR
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K48-linked Ubiquitination
Immune Response-regulating Signaling Pathway
Cellular Macromolecule Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Protein Modification Process
Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Regulation Of Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Activation Of Innate Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Proteolysis
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Cellular Response To Transforming Growth Factor Beta Stimulus
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Response To Transforming Growth Factor Beta
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination
Cellular Protein Metabolic Process
Positive Regulation Of Ligase Activity
Catabolic Process
Response To Organic Substance
Fc-epsilon Receptor Signaling Pathway
Cellular Response To Organic Substance
Immune Response
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Immune System Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Innate Immune Response
Defense Response
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Fc Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cell Death
Apoptotic Process
Death
Programmed Cell Death
Response To Stress
Neurotrophin TRK Receptor Signaling Pathway
Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Neurotrophin Signaling Pathway
Protein Metabolic Process
Response To Growth Factor
Innate Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Organic Substance
Cellular Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Cellular Protein Modification Process
Positive Regulation Of Cell Death
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Signaling
Positive Regulation Of Metabolic Process
Cell Communication
Regulation Of Kinase Activity
Regulation Of Cellular Component Organization
Regulation Of Protein Phosphorylation
Cellular Response To Stimulus
Protein Phosphorylation
Regulation Of Protein Kinase Activity
Response To Stimulus
Immune Response
Regulation Of Signaling
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Phosphorylation
Signal Transduction
Regulation Of Proteolysis
Regulation Of Signal Transduction
Tagcloud
?
1795g
2125g
abeta37
abeta39
abeta40
advance
dementia
dementias
doi
e599k
ejhg
fus
g709s
genetics
genotyping
granulin
grn
harbored
hek293
journal
lewy
neuropathological
pd
psen1
publically
publication
shifted
tar
variants
Tagcloud (Difference)
?
1795g
2125g
abeta37
abeta39
abeta40
advance
dementia
dementias
doi
e599k
ejhg
fus
g709s
genetics
genotyping
granulin
grn
harbored
hek293
journal
lewy
neuropathological
pd
psen1
publically
publication
shifted
tar
variants
Tagcloud (Intersection)
?