PFKM and ATP6V0A4

Number of citations of the paper that reports this interaction (PMID 12649290)
23

Data Source:
HPRD (in vivo, in vitro)

		PFKM	ATP6V0A4
Gene Name		phosphofructokinase, muscle	ATPase, H+ transporting, lysosomal V0 subunit a4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol 6-phosphofructokinase Complex Apical Plasma Membrane Extracellular Vesicular Exosome Sperm Principal Piece	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Integral Component Of Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Brush Border Membrane Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Fructose Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Positive Regulation Of Insulin Secretion Glucose Homeostasis Small Molecule Metabolic Process Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Protein Oligomerization	Ossification Cellular Iron Ion Homeostasis Regulation Of PH Vacuolar Acidification Excretion Sensory Perception Of Sound Insulin Receptor Signaling Pathway ATP Synthesis Coupled Proton Transport ATP Hydrolysis Coupled Proton Transport Proton Transport Transferrin Transport Interaction With Host Transmembrane Transport Vacuolar Proton-transporting V-type ATPase Complex Assembly Phagosome Maturation
Pathways		Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor
Drugs
Diseases
GWAS			F-cell distribution ( 21326311)
Protein-Protein Interactions		13 interactors: ATP6V0A4 CAV3 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PFKL SIAH1 UBTD1	1 interactors: PFKM
Entrez ID		5213	50617
HPRD ID		01988	05576
Ensembl ID		ENSG00000152556	ENSG00000105929
Uniprot IDs		P08237	Q9HBG4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Localization Heart Trabecula Formation Positive Regulation Of Organelle Organization Positive Regulation Of Histone Acetylation Myoblast Fusion Negative Regulation Of Potassium Ion Transport Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Heart Trabecula Morphogenesis Syncytium Formation Regulation Of Sodium Ion Transmembrane Transport Striated Muscle Cell Differentiation Negative Regulation Of Calcium Ion Transport Phagosome Maturation Regulation Of Histone Acetylation Regulation Of Signaling Trabecula Morphogenesis Positive Regulation Of Transport Myotube Differentiation Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transport Muscle Cell Differentiation Regulation Of Sodium Ion Transport Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Apolipoprotein Binding Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Cardiac Muscle Cell Development Anatomical Structure Morphogenesis Positive Regulation Of Histone Modification Cellular Metabolic Process Regulation Of Cardiac Muscle Contraction Response To Stimulus Response To Organic Substance Regulation Of Vesicle-mediated Transport Cellular Nitrogen Compound Metabolic Process Regulation Of Organelle Organization Regulation Of Striated Muscle Contraction Negative Regulation Of Transport Leading Strand Elongation Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Ion Transport Regulation Of Intracellular Transport Regulation Of Signal Transduction Interaction With Host Cardiac Muscle Cell Differentiation Response To Heat	Fructose 6-phosphate Metabolic Process Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Positive Regulation Of Insulin Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Glycolytic Process Positive Regulation Of Hormone Secretion Pyruvate Metabolic Process Carbohydrate Catabolic Process Glucose Metabolic Process Positive Regulation Of Protein Secretion Regulation Of Insulin Secretion Glucose Homeostasis Pathogenesis Hexose Metabolic Process Regulation Of Peptide Hormone Secretion Cellular Carbohydrate Metabolic Process Monosaccharide Metabolic Process Regulation Of Hormone Secretion Positive Regulation Of Secretion Positive Regulation Of Protein Transport Regulation Of Protein Secretion Generation Of Precursor Metabolites And Energy Protein Oligomerization
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