PFKM and PFKL

Number of citations of the paper that reports this interaction (PMID 6444721)
15

Data Source:
HPRD (in vitro)

		PFKM	PFKL
Gene Name		phosphofructokinase, muscle	phosphofructokinase, liver
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol 6-phosphofructokinase Complex Apical Plasma Membrane Extracellular Vesicular Exosome Sperm Principal Piece	Cytosol 6-phosphofructokinase Complex Membrane Extracellular Vesicular Exosome
	Molecular Function	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Fructose Binding	6-phosphofructokinase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Positive Regulation Of Insulin Secretion Glucose Homeostasis Small Molecule Metabolic Process Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Protein Oligomerization	Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Carbohydrate Phosphorylation Protein Oligomerization Protein Homotetramerization
Pathways		Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS			Rheumatoid arthritis ( 21505073)
Protein-Protein Interactions		13 interactors: ATP6V0A4 CAV3 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PFKL SIAH1 UBTD1	12 interactors: APP ATN1 COPS6 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PFKM PRPF40A TESK1 YWHAQ
Entrez ID		5213	5211
HPRD ID		01988	01385
Ensembl ID		ENSG00000152556	ENSG00000141959
Uniprot IDs		P08237	P17858 Q7L2M7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Localization Heart Trabecula Formation Positive Regulation Of Organelle Organization Positive Regulation Of Histone Acetylation Myoblast Fusion Negative Regulation Of Potassium Ion Transport Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Heart Trabecula Morphogenesis Syncytium Formation Regulation Of Sodium Ion Transmembrane Transport Striated Muscle Cell Differentiation Negative Regulation Of Calcium Ion Transport Phagosome Maturation Regulation Of Histone Acetylation Regulation Of Signaling Trabecula Morphogenesis Positive Regulation Of Transport Myotube Differentiation Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transport Muscle Cell Differentiation Regulation Of Sodium Ion Transport Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Apolipoprotein Binding Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Cardiac Muscle Cell Development Anatomical Structure Morphogenesis Positive Regulation Of Histone Modification Cellular Metabolic Process Regulation Of Cardiac Muscle Contraction Response To Stimulus Response To Organic Substance Regulation Of Vesicle-mediated Transport Cellular Nitrogen Compound Metabolic Process Regulation Of Organelle Organization Regulation Of Striated Muscle Contraction Negative Regulation Of Transport Leading Strand Elongation Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Ion Transport Regulation Of Intracellular Transport Regulation Of Signal Transduction Interaction With Host Cardiac Muscle Cell Differentiation Response To Heat
Tagcloud ?			aerobic ambiguous biogenesis biomass cd147 contributed differing export facilitated finger glut1 glycolysis glycoprotein hcc lactate mct1 mediators metabolism nuclease p53r2 pgc1alpha reprogrammed reprogramming rnai supplies systematically tfam transmembrane warburg
Tagcloud (Difference) ?			aerobic ambiguous biogenesis biomass cd147 contributed differing export facilitated finger glut1 glycolysis glycoprotein hcc lactate mct1 mediators metabolism nuclease p53r2 pgc1alpha reprogrammed reprogramming rnai supplies systematically tfam transmembrane warburg
Tagcloud (Intersection) ?