SH3GL1 and DNM1L

Number of citations of the paper that reports this interaction (PubMedID 18330356)
0

Data Source:
BioGRID (two hybrid)

		SH3GL1	DNM1L
Description		SH3 domain containing GRB2 like 1, endophilin A2	dynamin 1 like
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Brush Border Clathrin-coated Pit Endomembrane System Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Mitochondrion-derived Vesicle
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Microtubule Binding Lipid Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Mitochondrial Fission Calcium Ion Transport Endocytosis Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Gene Expression Regulation Of Mitochondrion Organization Programmed Cell Death Peroxisome Fission Mitochondrial Fragmentation Involved In Apoptotic Process Intracellular Distribution Of Mitochondria Rhythmic Process Positive Regulation Of Protein Secretion Protein Complex Oligomerization Heart Contraction Protein Localization To Mitochondrion Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Mitocytosis Regulation Of Peroxisome Organization Regulation Of Mitophagy Positive Regulation Of Secretion By Cell Regulation Of ATP Metabolic Process
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Apoptotic execution phase
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)	Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ	23 interacting genes: CAP2 FILNC1 FIS1 FZR1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF1 MIEF2 MUL1 PINK1 PRKN RRM2 SCG3 SENP3 SH3GL1 SIRT3 SUMO2 USP16 VIM ZBTB24
Entrez ID		6455	10059
HPRD ID		03462	04833
Ensembl ID		ENSG00000141985	ENSG00000087470
Uniprot IDs		Q6FGM0 Q99961	B4DYR6 O00429
PDB IDs			3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V 5WP9 8T1H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission	Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Mitochondrial Fission Mitochondrion Organization Mitochondrial Outer Membrane Peroxisome Positive Regulation Of Organelle Organization Positive Regulation Of Type 2 Mitophagy Regulation Of Mitochondrial Fusion Cellular Response To Toxic Substance Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitophagy Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Modification Process Regulation Of Proteolysis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Mitochondrial Fusion Response To Hydrogen Sulfide Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Modification Process Lewy Body Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitophagy Negative Regulation Of Mitochondrial Fusion Ubiquitin Protein Ligase Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Positive Regulation Of Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Post-translational Protein Modification Regulation Of Protein Metabolic Process
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