SH3GL1 and DPYSL4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SH3GL1	DPYSL4
Description		SH3 domain containing GRB2 like 1, endophilin A2	dihydropyrimidinase like 4
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Pyrimidine Nucleobase Catabolic Process Nervous System Development
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ	9 interacting genes: DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIM54 TRIP13 WEE2-AS1
Entrez ID		6455	10570
HPRD ID		03462	07463
Ensembl ID		ENSG00000141985	ENSG00000151640
Uniprot IDs		Q6FGM0 Q99961	O14531
PDB IDs			5NKS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission	Glutamatergic Synapse Negative Regulation Of Cellular Component Organization Central Nervous System Development Presynapse Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Glomerular Filtration Negative Regulation Of Retinal Ganglion Cell Axon Guidance Filtration Diaphragm Assembly Slit Diaphragm Assembly Lipid Binding Signal Transduction Endocytosis Identical Protein Binding System Development Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Clathrin-dependent Endocytosis Meiotic Recombination Checkpoint Signaling MRNA CDS Binding Pre-mRNA 5'-splice Site Binding Postsynaptic Endosome
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