SH3GL1 and RHEX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3GL1	RHEX
Description		SH3 domain containing GRB2 like 1, endophilin A2	regulator of hemoglobinization and erythroid cell expansion
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse	Plasma Membrane Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding	Erythropoietin Receptor Binding Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Cell Differentiation Cellular Response To Erythropoietin Erythropoietin-mediated Signaling Pathway Erythrocyte Maturation Positive Regulation Of Erythrocyte Differentiation
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ	7 interacting genes: GAD2 GET3 PBX3 RBFA SH3GL1 SH3GLB1 SNX1
Entrez ID		6455	440712
HPRD ID		03462	17400
Ensembl ID		ENSG00000141985	ENSG00000263961
Uniprot IDs		Q6FGM0 Q99961	Q6ZWK4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission	Posterior Compartment Specification Anterior Compartment Pattern Formation Lipid Binding Cadherin Binding Protein Localization To Vacuolar Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity GET Complex Compartment Pattern Specification Retromer, Tubulation Complex Leptin Receptor Binding 'de Novo' Post-translational Protein Folding Positive Regulation Of Membrane Tubulation Dorsal Spinal Cord Development Autophagic Cell Death Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Early Endosome Membrane Lamellipodium Morphogenesis Phosphatidylinositol 3-kinase Activator Activity Carbon-carbon Lyase Activity 'de Novo' Protein Folding
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