SH3GL1 and GPKOW

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3GL1	GPKOW
Description		SH3 domain containing GRB2 like 1, endophilin A2	G-patch domain and KOW motifs
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Spliceosomal Complex
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ	47 interacting genes: APP ARMCX1 BUD13 CCDC57 CNKSR3 DDIT4L EFHC2 FBXO7 GMPPA GOLGA2 GSTM5 HOOK2 HSF2BP IKBKG KANK2 LNX1 LRP2BP LZTS1 MAD1L1 MEOX2 MESD MID2 MTUS2 NINL OGT PHF1 PIBF1 PICK1 POLR2G PPP1CA PRKAR1B PRPF4 PRPF8 REL ROPN1 SH3GL1 SORBS3 SPDYE4 TCEA1 TCEA2 TRAF2 TRIM23 TRIM27 VPS52 WDR77 WDR83 ZMYND12
Entrez ID		6455	27238
HPRD ID		03462	06737
Ensembl ID		ENSG00000141985	ENSG00000068394
Uniprot IDs		Q6FGM0 Q99961	Q92917
PDB IDs			7DVQ 7QTT 8CH6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission	Cytoplasm Protein Binding Identical Protein Binding Regulation Of Autophagy Positive Regulation Of Autophagy
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