SH3GL1 and FBXO32

Number of citations of the paper that reports this interaction (PubMedID 27720640)
58

Data Source:
BioGRID (pull down, imaging technique)

		SH3GL1	FBXO32
Description		SH3 domain containing GRB2 like 1, endophilin A2	F-box protein 32
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Z Disc
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding	Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Cellular Response To Dexamethasone Stimulus
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Neddylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)	Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998 29785010 30054594 31959993) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603)
Interacting Genes		35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ	13 interacting genes: CDC34 CDK2 EIF3F KDM2A MLH1 MYC MYOD1 MYOG SH3GL1 SH3GL2 SH3GL3 SKP1 TTN
Entrez ID		6455	114907
HPRD ID		03462	05966
Ensembl ID		ENSG00000141985	ENSG00000156804
Uniprot IDs		Q6FGM0 Q99961	I6L984 Q0VAQ6 Q498Y9 Q969P5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission	Myotube Differentiation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle E-box Binding Striated Muscle Cell Differentiation Skeletal Muscle Cell Differentiation Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Development Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Muscle Cell Development Muscle Cell Differentiation Chromosome Organization Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Mitotic Cell Cycle Phase Transition Central Nervous System Development Skeletal Muscle Fiber Development Cell Cycle Phase Transition Cellular Response To Cytokine Stimulus Myotube Cell Development Protein Dimerization Activity Condensed Chromosome Cellular Response To Estradiol Stimulus Regulation Of Striated Muscle Tissue Development Detection Of Mechanical Stimulus Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Response To Peptide Response To Cytokine Transcription Regulator Complex Male Germ Cell Nucleus Condensed Nuclear Chromosome Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Presynapse Double-strand Break Repair Via Nonhomologous End Joining Euchromatin Identical Protein Binding Positive Regulation Of DNA Metabolic Process
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