SH3GL1 and PTPRO

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SH3GL1	PTPRO
Description		SH3 domain containing GRB2 like 1, endophilin A2	protein tyrosine phosphatase receptor type O
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse	Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Slit Diaphragm Assembly Regulation Of Synapse Organization Podocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Signaling by NTRK3 (TRKC)
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)	Cognitive function ( 22126837) General cognitive ability ( 29844566) Glomerular filtration rate (creatinine) ( 26831199) Homeostasis model assessment of insulin resistance ( 33381925) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Intelligence (MTAG) ( 29326435) Metamizole-induced agranulocytosis or neutropenia ( 33138277) Obstetric antiphospholipid syndrome ( 28424481) Temporal pole volume ( 31530798)
Interacting Genes		35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ	10 interacting genes: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 UFL1 YWHAZ
Entrez ID		6455	5800
HPRD ID		03462	02784
Ensembl ID		ENSG00000141985	ENSG00000151490
Uniprot IDs		Q6FGM0 Q99961	Q16827
PDB IDs			2G59 2GJT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission	Basal Body Patch Regulation Of Endocytosis Developmental Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Presynapse Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Myeloid Cell Development System Development Central Nervous System Development Regulation Of Long-term Neuronal Synaptic Plasticity Visual Behavior Regulation Of Immune Response Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Defense Response Defense Response To Bacterium Neuron Recognition Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Negative Regulation Of Immune Response Negative Regulation Of TORC1 Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cardioblast Proliferation UFM1 Ligase Activity Cellular Response To Type II Interferon Erythrocyte Differentiation Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Defense Response Cellular Component Assembly Acetylcholine Receptor Activator Activity Regulation Of Immune System Process Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Neuron Differentiation Lipoprotein Particle Positive Regulation Of Protein Import Phosphorylation Negative Regulation Of TOR Signaling
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