SH3GL1 and EEIG1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SH3GL1	EEIG1
Description		SH3 domain containing GRB2 like 1, endophilin A2	estrogen-induced osteoclastogenesis regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse	Nucleus Cytoplasm Membrane Membrane Raft
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding	Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Positive Regulation Of Osteoclast Differentiation
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ	9 interacting genes: BCAR1 CFTR CYSRT1 ENKD1 NEDD9 PFDN5 SH3GL1 SKAP1 SKAP2
Entrez ID		6455	399665
HPRD ID		03462	13262
Ensembl ID		ENSG00000141985	ENSG00000167106
Uniprot IDs		Q6FGM0 Q99961	Q5T9C2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Anchoring Junction Immunological Synapse Positive Regulation Of Immunological Synapse Formation Integrin-mediated Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly SH3 Domain Binding T Cell Receptor Signaling Pathway
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