DNM1L and CAP2

Number of citations of the paper that reports this interaction (PubMedID 30639852)
62

Data Source:
BioGRID (two hybrid)

		DNM1L	CAP2
Description		dynamin 1 like	cyclase associated actin cytoskeleton regulatory protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Brush Border Clathrin-coated Pit Endomembrane System Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Mitochondrion-derived Vesicle	Cytoplasm Plasma Membrane Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Microtubule Binding Lipid Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity	Actin Binding Protein Binding Adenylate Cyclase Binding Identical Protein Binding
	Biological Process	Mitochondrial Fission Calcium Ion Transport Endocytosis Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Gene Expression Regulation Of Mitochondrion Organization Programmed Cell Death Peroxisome Fission Mitochondrial Fragmentation Involved In Apoptotic Process Intracellular Distribution Of Mitochondria Rhythmic Process Positive Regulation Of Protein Secretion Protein Complex Oligomerization Heart Contraction Protein Localization To Mitochondrion Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Mitocytosis Regulation Of Peroxisome Organization Regulation Of Mitophagy Positive Regulation Of Secretion By Cell Regulation Of ATP Metabolic Process	Cell Morphogenesis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Presynaptic Actin Cytoskeleton Organization
Pathways		Apoptotic execution phase	Role of ABL in ROBO-SLIT signaling
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494)	Haemorrhoidal disease ( 33888516) Height ( 18391951) Mitochondrial DNA levels ( 25240745) QT interval ( 29213071) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834)
Interacting Genes		23 interacting genes: CAP2 FILNC1 FIS1 FZR1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF1 MIEF2 MUL1 PINK1 PRKN RRM2 SCG3 SENP3 SH3GL1 SIRT3 SUMO2 USP16 VIM ZBTB24	11 interacting genes: ACTG1 ADO ALAS1 CAP1 CFL2 DNM1L DSCAM GRXCR1 MT1P3 PRPF40A YWHAE
Entrez ID		10059	10486
HPRD ID		04833	10808
Ensembl ID		ENSG00000087470	ENSG00000112186
Uniprot IDs		B4DYR6 O00429	B7Z385 E9PDI2 P40123
PDB IDs		3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V 5WP9 8T1H
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Mitochondrial Fission Mitochondrion Organization Mitochondrial Outer Membrane Peroxisome Positive Regulation Of Organelle Organization Positive Regulation Of Type 2 Mitophagy Regulation Of Mitochondrial Fusion Cellular Response To Toxic Substance Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitophagy Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Modification Process Regulation Of Proteolysis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Mitochondrial Fusion Response To Hydrogen Sulfide Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Modification Process Lewy Body Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitophagy Negative Regulation Of Mitochondrial Fusion Ubiquitin Protein Ligase Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Positive Regulation Of Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Post-translational Protein Modification Regulation Of Protein Metabolic Process
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