SH3BP2 and CTTN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3BP2	CTTN
Description		SH3 domain binding protein 2	cortactin
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GO Annotations	Cellular Component		Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding
	Biological Process	Signal Transduction	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			RHO GTPases activate PAKs Clathrin-mediated endocytosis
Drugs
Diseases		Cherubism
GWAS		Hodgkin's lymphoma ( 34216518) Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)
Interacting Genes		31 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3
Entrez ID		6452	2017
HPRD ID		03657	01268
Ensembl ID		ENSG00000087266	ENSG00000085733
Uniprot IDs		A0A384N6E5 P78314	Q14247 Q53HG7
PDB IDs		2CR4 3TWR	1X69 2D1X
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Regulation Of Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Activation Of Immune Response Cell Motility Plasma Membrane Cell Migration Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Protein Kinase Activity Regulation Of Cell Activation Positive Regulation Of Immune Response T Cell Activation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of Immune Response Immune System Process	SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization
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