SH3BP2 and DBNL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		SH3BP2	DBNL
Description		SH3 domain binding protein 2	drebrin like
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GO Annotations	Cellular Component		Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Dendrite Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Anchoring Junction Presynapse Postsynapse Glutamatergic Synapse Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding	Actin Binding Protein Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Signal Transduction	Adaptive Immune Response Immune System Process Endocytosis Synapse Assembly Rac Protein Signal Transduction Neuron Projection Morphogenesis Membrane Organization Podosome Assembly Postsynaptic Actin Cytoskeleton Organization
Pathways			Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
Drugs
Diseases		Cherubism
GWAS		Hodgkin's lymphoma ( 34216518) Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)	Blood protein levels ( 30072576)
Interacting Genes		31 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	14 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 OGT POT1 SH2D4A SH3BP2 SHANK3 SYK TERF1 TERF2IP ZAP70
Entrez ID		6452	28988
HPRD ID		03657	06588
Ensembl ID		ENSG00000087266	ENSG00000136279
Uniprot IDs		A0A384N6E5 P78314	B4DUF9 Q9UJU6
PDB IDs		2CR4 3TWR	1X67
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Regulation Of Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Activation Of Immune Response Cell Motility Plasma Membrane Cell Migration Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Protein Kinase Activity Regulation Of Cell Activation Positive Regulation Of Immune Response T Cell Activation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of Immune Response Immune System Process	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Beta Selection Regulation Of Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Phosphatase Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Chromosome, Telomeric Region Negative Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Neuron Spine Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance In Response To DNA Damage Positive Regulation Of DNA Metabolic Process T Cell Receptor Complex Positive Regulation Of Signal Transduction Chromosome Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Alpha-beta T Cell Proliferation DNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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