SFTPD and LBR

Data Source: HiPPIP (Novel)

		SFTPD	LBR
Name		surfactant protein D	lamin B receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Lamina Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Identical Protein Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding Chromatin-protein Adaptor Activity
	Biological Process	Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Neutrophil Differentiation Random Inactivation Of X Chromosome
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity
Drugs		Beta-D-Glucose	None
Diseases		None	HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561 33909500 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Lung function (FEV1/FVC) ( 30804560 ) Rheumatoid arthritis ( 24390342 30423114 )	Delirium ( 29631748 ) LDL cholesterol levels in HIV infection ( 33109212 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )
Novel Interactors		9 novel interactors: CCN1 GPA33 KCNMA1 LBR PLAU PLXNA3 RBX1 SFTPA1 SMR3B	1 novel interactors: SFTPD
Interacting Genes		3 interacting genes: DCN DMBT1 MFAP4	13 interacting genes: AKAP8L CALD1 CBX3 CBX5 CD81 FNBP4 H4C14 KPNB1 LMNB1 PRM1 SRPK1 SRPK2 YWHAG
Entrez ID		6441	3930
HPRD ID		01522	02488
Ensembl ID		ENSG00000133661	ENSG00000143815
Uniprot IDs		P35247	Q14739
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS	2DIG
GO Terms Enriched among Interactors		Extracellular Space Extracellular Matrix Extracellular Region Extracellular Matrix Binding	Chromatin Organization Nuclear Envelope Protein Localization To Organelle Nucleoplasm Chromatin Remodeling Heterochromatin Formation Nuclear Matrix Chromosome Sperm DNA Condensation Positive Regulation Of Viral Genome Replication Pericentric Heterochromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Chromosome Condensation Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Gene Expression Protein Domain Specific Binding RNA Binding Nuclear Inner Membrane Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Site Of DNA Damage Heterochromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Viral Process Epigenetic Regulation Of Gene Expression Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Gene Expression Structural Constituent Of Nuclear Lamina Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Protein Localization To Vacuole Myoblast Fusion Involved In Skeletal Muscle Regeneration Nucleus Organization Chromosome Organization Protein Kinase C Inhibitor Activity Chromatin Lock Complex Regulation Of Macromolecule Metabolic Process Actin Cap Regulation Of T Cell Mediated Immunity Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus RNA Splicing Nuclear Speck Organization Senescence-associated Heterochromatin Focus