SFTPD and KCNMA1

		SFTPD	KCNMA1
Description		surfactant protein D	potassium calcium-activated channel subfamily M alpha 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex Postsynaptic Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Identical Protein Binding	Actin Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Identical Protein Binding Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process	Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Response To Osmotic Stress Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Response To Carbon Monoxide Vasodilation Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Transmembrane Transport Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells
Drugs		Beta-D-Glucose	Chlorzoxazone Bendroflumethiazide Procaine Hydroflumethiazide Ritodrine Hydrochlorothiazide Nitrendipine Miconazole Diazoxide Halothane Colforsin Dequalinium Trimebutine
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 24390342 30423114)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Blood pressure ( 24954895) Bone mineral density (spine) ( 26911590) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31015462 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucocorticoid-induced osteonecrosis ( 26265699) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 28869591 30598549) Hypospadias ( 25108383) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 31959993) Lean body mass ( 28552196) Lumbar spine bone mineral density ( 29499414 22504420) Male-pattern baldness ( 28196072) Mortality in heart failure ( 20400778) Myopia ( 27182965) Obesity ( 21708048) Refractive error ( 32231278) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556) Schizophrenia ( 33169155) Smoking cessation in chronic obstructive pulmonary disease ( 29631575) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		3 interacting genes: DCN DMBT1 MFAP4	6 interacting genes: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2
Entrez ID		6441	3778
HPRD ID		01522	15967
Ensembl ID		ENSG00000133661	ENSG00000156113
Uniprot IDs		P35247	A0A087WZL8 A0A1W2PNQ3 A0A1W2PNW6 A0A1W2PP94 A0A1W2PPY5 A0A1W2PQ61 A0A1W2PQA0 A0A1W2PQK5 A0A1W2PQU4 A0A1W2PR56 A0A1W2PR62 A0A1W2PRB0 A0A1W2PRN5 A0A1W2PSD3 B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ7 Q5SVJ8 Q5SVJ9 S4R453
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS	2K44 3MT5 3NAF 6ND0 6V22 6V35 6V38 6V3G 6V5A 7YNZ 7YO0 7YO1 7YO2 7YO3 7YO4 7YO5 8GH9 8GHF 8GHG 8V60 8V63 8V64 8VAV 8VAZ 8Z3S 9CZH 9CZJ 9CZK 9CZM 9CZO 9CZQ 9D18 9D19 9JO3 9JO4
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Matrix Extracellular Region Extracellular Matrix Binding
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