SFTPD

Gene Name		surfactant protein D
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Trimer Extracellular Space Lysosome Endocytic Vesicle
	Molecular Function	Protein Binding Carbohydrate Binding
	Biological Process	Regulation Of Cytokine Production Receptor-mediated Endocytosis Respiratory Gaseous Exchange Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Negative Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Signal regulatory protein (SIRP) family interactions Innate Immune System
Drugs		Beta-D-Glucose
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-protein Interactions		3 interactors: DCN DMBT1 MFAP4
Entrez ID		6441
HPRD ID		01522
Ensembl ID		ENSG00000133661
Uniprot IDs		P35247
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52
Enriched GO Terms of Interacting Partners?		Induction Of Bacterial Agglutination Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To UV-B Elastic Fiber Assembly Response To Bacterium Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Extracellular Fibril Organization Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process UV Protection Extracellular Matrix Assembly Response To UV-B Response To Other Organism Chondroitin Sulfate Biosynthetic Process Inner Cell Mass Cell Proliferation Response To Biotic Stimulus Chondroitin Sulfate Proteoglycan Biosynthetic Process Antibacterial Humoral Response Antimicrobial Humoral Response Blastocyst Growth Regulation Of Collagen Metabolic Process Peptide Cross-linking Response To Abiotic Stimulus Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Cellular Response To UV Positive Regulation Of Epithelial Cell Differentiation
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