SFTPD and PLXNA3

		SFTPD	PLXNA3
Description		surfactant protein D	plexin A3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Semaphorin Receptor Complex Plasma Membrane Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Identical Protein Binding	Protein Binding Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process	Cell Surface Receptor Signaling Pathway Axon Guidance Synapse Assembly Motor Neuron Axon Guidance Telencephalon Development Facial Nerve Structural Organization Olfactory Nerve Formation Trigeminal Nerve Structural Organization Hippocampus Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Pyramidal Neuron Development Regulation Of Cell Migration Axon Extension Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Regulation Of Axonogenesis Negative Chemotaxis Regulation Of Chemotaxis Positive Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Neuron Projection Extension
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling
Drugs		Beta-D-Glucose
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		3 interacting genes: DCN DMBT1 MFAP4	8 interacting genes: CSNK2B MAPK8IP2 MTDH PPP2CB SMN1 TK1 TRIM55 TRIM63
Entrez ID		6441	55558
HPRD ID		01522	02062
Ensembl ID		ENSG00000133661	ENSG00000130827
Uniprot IDs		P35247	P51805
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Matrix Extracellular Region Extracellular Matrix Binding	Macrophage Migration
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