LBR

Name	lamin B receptor
Structure
Novel Interactors	1 novel interactors: SFTPD
Interactors	13 interactors: AKAP8L CALD1 CBX3 CBX5 CD81 FNBP4 H4C14 KPNB1 LMNB1 PRM1 SRPK1 SRPK2 YWHAG
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Lamina Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding Chromatin-protein Adaptor Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Neutrophil Differentiation Random Inactivation Of X Chromosome
Pathways	Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity
Diseases	HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS	Delirium ( 29631748 ) LDL cholesterol levels in HIV infection ( 33109212 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )
Entrez ID	3930
HPRD ID	02488
Ensembl ID	ENSG00000143815
Uniprot IDs	Q14739
PDB IDs	2DIG
GO Terms Enriched among Interactors ?	Chromatin Organization Nuclear Envelope Protein Localization To Organelle Nucleoplasm Chromatin Remodeling Heterochromatin Formation Nuclear Matrix Chromosome Sperm DNA Condensation Positive Regulation Of Viral Genome Replication Pericentric Heterochromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Chromosome Condensation Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Gene Expression Protein Domain Specific Binding RNA Binding Nuclear Inner Membrane Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Site Of DNA Damage Heterochromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Viral Process Epigenetic Regulation Of Gene Expression Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Gene Expression Structural Constituent Of Nuclear Lamina Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Protein Localization To Vacuole Myoblast Fusion Involved In Skeletal Muscle Regeneration Nucleus Organization Chromosome Organization Protein Kinase C Inhibitor Activity Chromatin Lock Complex Regulation Of Macromolecule Metabolic Process Actin Cap Regulation Of T Cell Mediated Immunity Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus RNA Splicing Nuclear Speck Organization Senescence-associated Heterochromatin Focus