SFTPD and MFAP4

Number of citations: 0 (PubMedID 10542261)
Data Source: HPRD (in vivo)

		SFTPD	MFAP4
Name		surfactant protein D	microfibril associated protein 4
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Microfibril Extracellular Region Extracellular Space Extracellular Matrix Elastic Fiber
	Molecular Function	Protein Binding Carbohydrate Binding Identical Protein Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process	Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Elastic Fiber Assembly Cellular Response To UV-B Supramolecular Fiber Organization
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Molecules associated with elastic fibres
Drugs		Beta-D-Glucose	None
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561 33909500 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Lung function (FEV1/FVC) ( 30804560 ) Rheumatoid arthritis ( 24390342 30423114 )	Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		3 interacting genes: DCN DMBT1 MFAP4	2 interacting genes: RNF115 SFTPD
Entrez ID		6441	4239
HPRD ID		01522	02789
Ensembl ID		ENSG00000133661	ENSG00000166482
Uniprot IDs		P35247	P55083
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS	7ZMK 8UN7
GO Terms Enriched among Interactors		Extracellular Space Extracellular Matrix Extracellular Region Extracellular Matrix Binding	None