SFTPD and MFAP4

Number of citations of the paper that reports this interaction (PMID 10542261)
7

Data Source:
HPRD (in vivo)

		SFTPD	MFAP4
Gene Name		surfactant protein D	microfibrillar-associated protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Trimer Extracellular Space Lysosome Endocytic Vesicle	Microfibril Extracellular Region Extracellular Matrix Extracellular Vesicular Exosome Elastic Fiber
	Molecular Function	Protein Binding Carbohydrate Binding	Molecular_function Protein Binding
	Biological Process	Regulation Of Cytokine Production Receptor-mediated Endocytosis Respiratory Gaseous Exchange Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Negative Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process	Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Extracellular Matrix Organization Extracellular Fibril Organization Elastic Fiber Assembly Cellular Response To UV-B
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Signal regulatory protein (SIRP) family interactions Innate Immune System	Molecules associated with elastic fibres Elastic fibre formation
Drugs		Beta-D-Glucose
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		3 interactors: DCN DMBT1 MFAP4	2 interactors: RNF115 SFTPD
Entrez ID		6441	4239
HPRD ID		01522	02789
Ensembl ID		ENSG00000133661	ENSG00000166482
Uniprot IDs		P35247	P55083
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52
Enriched GO Terms of Interacting Partners?		Induction Of Bacterial Agglutination Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To UV-B Elastic Fiber Assembly Response To Bacterium Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Extracellular Fibril Organization Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process UV Protection Extracellular Matrix Assembly Response To UV-B Response To Other Organism Chondroitin Sulfate Biosynthetic Process Inner Cell Mass Cell Proliferation Response To Biotic Stimulus Chondroitin Sulfate Proteoglycan Biosynthetic Process Antibacterial Humoral Response Antimicrobial Humoral Response Blastocyst Growth Regulation Of Collagen Metabolic Process Peptide Cross-linking Response To Abiotic Stimulus Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Cellular Response To UV Positive Regulation Of Epithelial Cell Differentiation	Negative Regulation Of Interleukin-2 Biosynthetic Process Surfactant Homeostasis Chemical Homeostasis Within A Tissue Macrophage Chemotaxis Negative Regulation Of Interleukin-2 Production Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Interleukin-2 Biosynthetic Process Protein K63-linked Ubiquitination Negative Regulation Of Cytokine Biosynthetic Process Protein K48-linked Ubiquitination Protein Autoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Phagocytosis Lung Alveolus Development Respiratory Gaseous Exchange Negative Regulation Of T Cell Proliferation Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Leukocyte Proliferation Regulation Of ERBB Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Chemotaxis Positive Regulation Of Endocytosis Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cytokine Biosynthetic Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation
Tagcloud ?			acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 morphants morpholino mpx myelopoiesis ncor1 ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Difference) ?			acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 morphants morpholino mpx myelopoiesis ncor1 ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Intersection) ?